protein secretion;
protein misfolding;
Sec61;
channel;
retrotranslocation;
proteasome;
D O I:
10.1146/annurev.cellbio.21.012704.133250
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Secretory and transmembrane proteins enter the secretory pathway through the protein-conductin Sec61 channel in the membrane of the endoplasmic reticulum. In the endoplasmic reticulum, proteins are frequently covalently modified, and oligomerize before they fold, are packaged into transport vesicles that shuttle them to the Golgi complex. Proteins that misfold in the endoplasmic reticulum are selectively transported back across the endoplasmic reticulum membrane to the cytosol for degradation by proteasomes. Depending on the topology of the defect in the protein, cytosolic or lumenal chaperones are involved in its targeting to degradation. The export channel for misfolded proteins is likely also formed by Sec61p. Export may be powered by AAA-ATPases of the proteasome 19S regulatory particle or Cdc48p/p97. Exported proteins are frequently ubiquitylated prior to degradation and are escorted to the proteasome by polyubiquitin-binding proteins.
机构:
Univ Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USAUniv Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USA
Caldwell, SR
Hill, KJ
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机构:
Univ Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USAUniv Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USA
Hill, KJ
Cooper, AA
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h-index: 0
机构:
Univ Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USAUniv Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USA
机构:
NCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USANCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USA
Dai, RM
Li, CCH
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h-index: 0
机构:
NCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USANCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USA
机构:
Univ Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USAUniv Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USA
Caldwell, SR
Hill, KJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USAUniv Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USA
Hill, KJ
Cooper, AA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USAUniv Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USA
机构:
NCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USANCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USA
Dai, RM
Li, CCH
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USANCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USA