Reproducibility of MR-based liver fat quantification across field strength: Same-day comparison between 1.5T and 3T in obese subjects

被引:78
作者
Artz, Nathan S. [1 ]
Haufe, William M. [2 ]
Hooker, Catherine A. [2 ]
Hamilton, Gavin [2 ]
Wolfson, Tanya [3 ]
Campos, Guilherme M. [4 ]
Gamst, Anthony C. [3 ]
Schwimmer, Jeffrey B. [2 ,5 ,6 ]
Sirlin, Claude B. [2 ]
Reeder, Scott B. [1 ,7 ,8 ,9 ,10 ]
机构
[1] Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA
[2] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA
[3] Univ Calif San Diego, Dept Computat & Appl Stat Lab, San Diego, CA 92103 USA
[4] Univ Wisconsin, Dept Surg, Madison, WI USA
[5] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA
[6] Rady Childrens Hosp, Dept Gastroenterol, San Diego, CA USA
[7] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA
[8] Univ Wisconsin, Dept Biomed Engn, Madison, WI USA
[9] Univ Wisconsin, Dept Med, Madison, WI USA
[10] Univ Wisconsin, Dept Emergency Med, Madison, WI USA
基金
美国国家卫生研究院;
关键词
reproducibility; magnetic resonance imaging; fat quantification; proton density fat-fraction; liver; chemical shift; obesity; MAGNETIC-RESONANCE-SPECTROSCOPY; HEPATIC STEATOSIS; SAMPLING VARIABILITY; BARIATRIC SURGERY; FLIP-ANGLE; IN-VIVO; VALIDATION; SEPARATION; FRACTION; DISEASE;
D O I
10.1002/jmri.24842
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
100231 [临床病理学]; 100902 [航空航天医学];
摘要
PurposeTo examine the reproducibility of quantitative magnetic resonance (MR) methods to estimate hepatic proton density fat-fraction (PDFF) at different magnetic field strengths. Materials and MethodsThis Health Insurance Portability and Accountability Act (HIPAA)-compliant study was approved by the Institutional Review Board. Following informed consent, 25 severely obese subjects (mean body mass index [BMI]: 454, range: 38-53 kg/m(2)) were scanned at 1.5T and 3T on the same day. Two confounder-corrected multiecho chemical shift-encoded gradient-echo-based imaging methods were acquired to estimate PDFF over the entire liver: 3D complex-based (MRI-C) and 2D magnitude-based (MRI-M) MRI. Single-voxel MR spectroscopy (MRS) was performed in the right liver lobe. Using linear regression, pairwise comparisons of estimated PDFF were made between methods (MRI-C, MRI-M, MRS) at each field strength and for each method across field strengths. Results1.5T vs. 3T regression analyses for MRI-C, MRI-M, and MRS PDFF measurements yielded R-2 values of 0.99, 0.97, and 0.90, respectively. The best-fit line was near unity (slope(m)=1, intercept(b)=0), indicating excellent agreement for each case: MRI-C (m=0.92 [0.87, 0.99], b=1.4 [0.7, 1.8]); MRI-M (m=1.0 [0.90, 1.08], b=-1.4 [-2.4, -0.5]); MRS (m=0.98 [0.82, 1.15], b=1.2 [-0.2, 3.0]). Comparing MRI-C and MRI-M yielded an R-2=0.98 (m=1.1 [1.02, 1.16], b=-1.8 [-2.8, -1.1]) at 1.5T, and R-2=0.99 (m=0.98 [0.93, 1.03], b=1.2 [0.7, 1.7]) at 3T. ConclusionThis study demonstrates that PDFF estimation is reproducible across field strengths and across two confounder-corrected MR-based methods. J. Magn. Reson. Imaging 2015;42:811-817.
引用
收藏
页码:811 / 817
页数:7
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