Giving cells a new sugar-coating

被引：3

作者：

Howarth, M ^{[1
]}

Ting, AY ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 03期

关键词：

D O I：

10.1038/nchembio0306-127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Looked at from the outside of the cell, proteins are often hidden behind a forest of sugar chains. Using a sugar analog to introduce thiols onto the tips of the branches of this forest alters cell attachment and has unexpected consequences for cell differentiation.

引用

收藏

页码：127 / 128

页数：2

相关论文

共 10 条

[1]

CHANDRA RA, 2005, ANGEW CHEM INT ED EN

[2]

Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase [J].

Chen, I ;

Howarth, M ;

Lin, WY ;

Ting, AY .

NATURE METHODS, 2005, 2 (02) :99-104

[3]

Metabolic oligosaccharide engineering as a tool for glycobiology [J].

Dube, DH ;

Bertozzi, CR .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (05) :616-625

[4]

Foster MM, 2003, CANCER RES, V63, P2775

[5]

Biochemical engineering of the N-acyl side chain of sialic acid:: biological implications [J].

Keppler, OT ;

Horstkorte, R ;

Pawlita, M ;

Schmidts, C ;

Reutter, W .

GLYCOBIOLOGY, 2001, 11 (02) :11R-18R

[6]

Engineering novel cell surface receptors for virus-mediated gene transfer [J].

Lee, JH ;

Baker, TJ ;

Mahal, LK ;

Zabner, J ;

Bertozzi, CR ;

Wiemer, DF ;

Welsh, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (31) :21878-21884

[7]

Chemical remodelling of cell surfaces in living animals [J].

Prescher, JA ;

Dube, DH ;

Bertozzi, CR .

NATURE, 2004, 430 (7002) :873-877

[8]

Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology [J].

Sampathkumar, SG ;

Li, AV ;

Jones, MB ;

Sun, ZH ;

Yarema, KJ .

NATURE CHEMICAL BIOLOGY, 2006, 2 (03) :149-152

[9]

Automated synthesis of oligosaccharides as a basis for drug discovery [J].

Seeberger, PH ;

Werz, DB .

NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (09) :751-763

[10]

An expanding genetic code [J].

Xie, JM ;

Schultz, PG .

METHODS, 2005, 36 (03) :227-238