The role of α9ß1 integrin and its ligands in the development of autoimmune diseases

被引：31

作者：

Kon, Shigeyuki ^{[1
]}

Uede, Toshimitsu ^{[2
]}

机构：

[1] Fukuyama Univ, Fac Pharmaceut Sci, Dept Mol Immunol, 985-1 Azasanzo,Higashimura Machi, Fukuyama, Hiroshima 7290292, Japan

[2] Hokkaido Univ, Inst Genet Med, Div Mol Neuroimmunol, Sapporo, Hokkaido 0600815, Japan

来源：

JOURNAL OF CELL COMMUNICATION AND SIGNALING | 2018年 / 12卷 / 01期

基金：

日本学术振兴会;

关键词：

alpha; 9; integrin; Autoimmune diseases; Multiple; sclerosis; Osteopontin; Rheumatoid arthritis; Tenascin-C; TENASCIN-C; CELL-ADHESION; ALPHA-9-BETA-1; INTEGRIN; ENDOTHELIAL-CELLS; OSTEOCLAST FORMATION; INTRINSIC REGULATOR; CYTOPLASMIC DOMAIN; ALPHA(9) INTEGRIN; INDUCED ARTHRITIS; GROWTH-FACTORS;

D O I：

10.1007/s12079-017-0413-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Adhesion of cells to extracellular matrix proteins through integrins expressed on the cell surface is important for cell adhesion/motility, survival, and differentiation. Recently, alpha 9 ss 1 integrin was reported to be important for the development of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, and their murine models. In addition, ligands for alpha 9 ss 1 integrin, such as osteopontin and tenascin-C, are well established as key regulators of autoimmune diseases. Therefore, this review focused on the role of interactions between alpha 9 ss 1 integrin and its ligands in the development of autoimmune diseases.

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收藏

页码：333 / 342

页数：10

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