PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis

被引：48

作者：

Corrente, G ^{[1
]}

Guardavaccaro, D ^{[1
]}

Tirone, F ^{[1
]}

机构：

[1] CNR, Ist Neurobiol, I-00156 Rome, Italy

来源：

NEUROREPORT | 2002年 / 13卷 / 04期

关键词：

apoptosis; cell cycle; differentiation; nerve growth factor; p21; proliferation;

D O I：

10.1097/00001756-200203250-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

PC3(TIS1/BTG2) is member of a novel family of antiproliferative genes (BTGI, ANA/BTG3, PC3B,TOB, and TOB2) that play a role in cellular differentiation. We have previously shown that PC3(TIS21/BTG2) is induced by nerve growth factor (NGF) at the onset of neuronal differentiation in the neural crest-derived PC12 cell line, and is a marker for neuronal birth. We now observe that PC3(TIS21/BTG2) ectopically expressed in PCI2 cells synergises with NGF, similarly to the cyclin-dependent kinase inhibitor p21, potentiating the induction of the neuronal markers tyrosine hydroxylase and neurofilament 160 kDa. Furthermore, PC3(TIS21/BTG2) protects from apoptosis elicited by NGF deprivation in terminally differentiated PC12 cultures. Such effects might be a consequence of the arrest of cell cycle exerted by PC3(TIS21/BTG2), or expression of a sensitising (neurogenic) property of the molecule.

引用

收藏

页码：417 / 422

页数：6

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