Mechanisms of Ovarian Cancer Metastasis: Biochemical Pathways

被引：52

作者：

Nakayama, Kentaro ^{[1
]}

Nakayama, Naomi ^{[2
]}

Katagiri, Hiroshi ^{[1
]}

Miyazaki, Kohji ^{[1
]}

机构：

[1] Shimane Univ, Dept Obstet & Gynecol, Sch Med, Izumo, Shimane 6938501, Japan

[2] Shimane Univ, Dept Biochem, Sch Med, Izumo, Shimane 6938501, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 09期

关键词：

cancer; metastasis suppressor gene; EMT; tumor microenvironment; MESENCHYMAL STEM-CELLS; SUPPRESSOR GENE; CARCINOMA-CELLS; E-CADHERIN; FAVORABLE PROGNOSIS; UP-REGULATION; TUMOR-CELLS; IN-VITRO; EXPRESSION; PROTEIN;

D O I：

10.3390/ijms130911705

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Ovarian cancer is the most lethal gynecologic malignancy. Despite advances in chemotherapy, the five-year survival rate of advanced ovarian cancer patients with peritoneal metastasis remains around 30%. The most significant prognostic factor is stage, and most patients present at an advanced stage with peritoneal dissemination. There is often no clearly identifiable precursor lesion; therefore, the events leading to metastatic disease are poorly understood. This article reviews metastatic suppressor genes, the epithelial-mesenchymal transition (EMT), and the tumor microenvironment as they relate to ovarian cancer metastasis. Additionally, novel chemotherapeutic agents targeting the metastasis-related biochemical pathways are discussed.

引用

页码：11705 / 11717

页数：13

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