Two new eudesmanolides from Inula racemosa and their bioactivities

被引：23

作者：

Zhang, Ting

Gong, Ting

Yang, Yan

Chen, Ruo-Yun ^{[1
]}

Yu, De-Quan

机构：

[1] Chinese Acad Med Sci, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100050, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2012年 / 5卷 / 02期

关键词：

Compositae; Inula racemosa; Eudesmanolide; Cytotoxic activity; Anti-inflammation; SESQUITERPENE LACTONES; PLANTS; ROOT;

D O I：

10.1016/j.phytol.2011.12.014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new eudesmane-type sesquiterpene lactones, 1-one-4-epi-alantolactone (1) and 4 alpha,13-dihydroxy-5,7-( 11)-eudesmadien-12,8-olide (2), were isolated from the roots of Inula racemosa, together with six known compounds (3-8). The cytotoxic activities against five human cancer cell lines had been tested and compounds 3, 6, 7 and 8 exhibited moderate cytotoxic activities. Compounds 4 and 8 showed potent in vitro activities against the release of beta-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF), with the inhibitory ratios 65.4% (P < 0.01) and 80.5% (P < 0.001), at concentration of 10 mM, respectively. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

引用

页码：229 / 232

页数：4

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