Sisyphus and Translational Stroke Research

被引：5

作者：

Lyden, Patrick ^{[1
]}

Lapchak, Paul ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 156期

关键词：

ACUTE ISCHEMIC-STROKE; TISSUE-PLASMINOGEN-ACTIVATOR; INFRARED-LASER THERAPY; CLINICAL RATING SCORES; QUANTAL BIOASSAY; EMBOLIC STROKES; NXY-059; DRUGS; MICROEMBOLI; ULTRASOUND;

D O I：

10.1126/scitranslmed.3005083

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

After more than 1000 failures, we know that our methods for translating efective stroke treatments from the laboratory to the clinic do not work. New preclinical and clinical approaches conceived outside of the current paradigm exist and should be carefully considered. Now, Tymianski and colleagues report on results obtained during translation of a new neuroprotectant.

引用

页数：4

共 30 条

[1] A Translational Paradigm for the Preclinical Evaluation of the Stroke Neuroprotectant Tat-NR2B9c in Gyrencephalic Nonhuman Primates [J].

Cook, Douglas J. ;

Teves, Lucy ;

Tymianski, Michael .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (154)

[2] Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing? [J].

De Keyser, J ;

Sulter, G ;

Luiten, PG .

TRENDS IN NEUROSCIENCES, 1999, 22 (12) :535-540

[3]

Enlimomab Acute Stroke Trial Investigators, 2001, NEUROLOGY, V57, P1428

[4] Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations [J].

Fisher, Marc ;

Feuerstein, Giora ;

Howells, David W. ;

Hurn, Patricia D. ;

Kent, Thomas A. ;

Savitz, Sean I. ;

Lo, Eng H. .

STROKE, 2009, 40 (06) :2244-2250

[5] WHY DO ALL DRUGS WORK IN ANIMALS BUT NONE IN STROKE PATIENTS .2. NEUROPROTECTIVE THERAPY [J].

GROTTA, J .

JOURNAL OF INTERNAL MEDICINE, 1995, 237 (01) :89-94

[6] Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke [J].

Hacke, Werner ;

Kaste, Markku ;

Bluhmki, Erich ;

Brozman, Miroslav ;

Davalos, Antoni ;

Guidetti, Donata ;

Larrue, Vincent ;

Lees, Kennedy R. ;

Medeghri, Zakaria ;

Machnig, Thomas ;

Schneider, Dietmar ;

von Kummer, Ruediger ;

Wahlgren, Nils ;

Toni, Danilo .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (13) :1317-1329

[7] Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial [J].

Hill, Michael D. ;

Martin, Renee H. ;

Mikulis, David ;

Wong, John H. ;

Silver, Frank L. ;

terBrugge, Karel G. ;

Milot, Genevieve ;

Clark, Wayne M. ;

MacDonald, R. Loch ;

Kelly, Michael E. ;

Boulton, Melford ;

Fleetwood, Ian ;

McDougall, Cameron ;

Gunnarsson, Thorsteinn ;

Chow, Michael ;

Lum, Cheemun ;

Dodd, Robert ;

Poublanc, Julien ;

Krings, Timo ;

Demchuk, Andrew M. ;

Goyal, Mayank ;

Anderson, Roberta ;

Bishop, Julie ;

Garman, David ;

Tymianski, Michael .

LANCET NEUROLOGY, 2012, 11 (11) :942-950

[8] CRITERIA FOR VALID PRECLINICAL TRIALS USING ANIMAL STROKE MODELS [J].

HSU, CY .

STROKE, 1993, 24 (05) :633-636

[9] ANIMAL-MODELS FOR THE STUDY OF DRUGS IN ISCHEMIC STROKE [J].

KARPIAK, SE ;

TAGLIAVIA, A ;

WAKADE, CG .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1989, 29 :403-414

[10] The (Un) Importance of Cerebral Microemboli [J].

Kruis, Rosalie W. J. ;

Vlasveld, Florine A. E. ;

Van Dijk, Diederik .

SEMINARS IN CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2010, 14 (02) :111-118

← 1 2 3 →