Molecular evidence for a critical period in mural trophoblast development in bovine blastocysts

被引:174
作者
Degrelle, SA
Campion, E
Cabau, C
Piumi, F
Reinaud, P
Richard, C
Renard, JP
Hue, I [1 ]
机构
[1] INRA, UMR, ENVA, CNRS Biol Dev & Reprod, F-78352 Jouy En Josas, France
[2] Agenae, Unite Math Informat & Genome, F-78352 Jouy En Josas, France
[3] INRA, UMR, CEA Radiobiol & Etude Genome, Ctr Ressources Biol Genom Animaux Elevages & Inte, F-78352 Jouy En Josas, France
[4] Unite Commune Expt Anim Bressonvilliers, F-91630 Lendeville, France
关键词
bovine; blastocyst; elongation; pre-implantation; trophoblast; epiblast; differentiation; transcripts; cDNA array; in situ hybridization;
D O I
10.1016/j.ydbio.2005.09.043
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Embryonic and extra-embryonic lineages are separated at the blastocyst stage in the mouse at the onset of implantation but well ahead of implantation in most mammals. To provide information on the development of the trophoblast lineage in late-implanting bovine embryos, we combined the use of molecular markers defining embryonic and extra-embryonic lineages in the mouse with a transcriptomie approach dedicated to the early steps of the elongation process, a characteristic feature of blastocyst development in ruminants, In this study, we present molecular evidence for differences between the cow and the mouse in the programming of trophoblast differentiation, This different programming encompasses: (i) the expression of epiblast specifying genes (Oct-4, Nanog) in bovine trophoblast cells at the onset of elongation, (ii) the transcription of proliferation markers in early elongating blastocysts, (iii) the early detection of trophoblast-specific transcripts related to extra-embryonic tissue's differentiation (Hand1, Ets2, IFN-tau) and (iv) the identification of a new transcript (c12) which displays a reciprocal pattern to that of Oct-4 and Nanog genes in the embryonic cells and for which no equivalent has thus far been found in the mouse. Altogether, these results tended to show that early elongation is a critical transition in bovine trophoblast development. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:448 / 460
页数:13
相关论文
共 73 条
[1]   Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the Fibroblast growth factor-4 enhancer [J].
Ambrosetti, DC ;
Schöler, HR ;
Dailey, L ;
Basilico, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (30) :23387-23397
[2]   Multipotent cell lineages in early mouse development depend on SOX2 function [J].
Avilion, AA ;
Nicolis, SK ;
Pevny, LH ;
Perez, L ;
Vivian, N ;
Lovell-Badge, R .
GENES & DEVELOPMENT, 2003, 17 (01) :126-140
[3]   THE ANATOMY AND PHYSIOLOGY OF PRE-ATTACHMENT BOVINE EMBRYOS [J].
BETTERIDGE, KJ ;
FLECHON, JE .
THERIOGENOLOGY, 1988, 29 (01) :155-187
[4]   Serial analysis of gene expression during elongation of the peri-implantation porcine trophectoderm (conceptus) [J].
Blomberg, LA ;
Long, EL ;
Sonstegard, TS ;
Van Tassell, CP ;
Dobrinsky, JR ;
Zuelke, KA .
PHYSIOLOGICAL GENOMICS, 2005, 20 (02) :188-194
[5]   Identification of differentially regulated genes during elongation and early implantation in the ovine trophoblast using complementary DNA array screening [J].
Cammas, L ;
Reinaud, P ;
Dubois, O ;
Bordas, N ;
Germain, G ;
Charpigny, G .
BIOLOGY OF REPRODUCTION, 2005, 72 (04) :960-967
[6]   DEVELOPMENT OF BOVINE BLASTOCYST WITH A NOTE ON IMPLANTATION [J].
CHANG, MC .
ANATOMICAL RECORD, 1952, 113 (02) :143-161
[7]   Cyclooxygenase-2 unlike cyclooxygenase-1 is highly expressed in ovine embryos during the implantation period [J].
Charpigny, G ;
Reinaud, P ;
Tamby, JP ;
Creminon, C ;
Guillomot, M .
BIOLOGY OF REPRODUCTION, 1997, 57 (05) :1032-1040
[8]   Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells [J].
Chew, JL ;
Loh, YH ;
Zhang, WS ;
Chen, X ;
Tam, WL ;
Yeap, LS ;
Li, P ;
Ang, YS ;
Lim, B ;
Robson, P ;
Ng, HH .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (14) :6031-6046
[9]   IFPA 2004 Award In Placentology Lecture - How to make a placenta: Mechanisms of trophoblast cell differentiation in mice - A review [J].
Cross, JC .
PLACENTA, 2005, 26 :S3-S9
[10]   Analysis of gene transcription in bovine nuclear transfer embryos reconstructed with granulosa cell nuclei [J].
Daniels, R ;
Hall, V ;
Trounson, AO .
BIOLOGY OF REPRODUCTION, 2000, 63 (04) :1034-1040