Influence of herbal combinations on the extraction efficiencies of chemical compounds from Cinnamomum cassia, Paeonia lactiflora, and Glycyrrhiza uralensis, the herbal components of Gyeji-tang, evaluated by HPLC method

被引：16

作者：

Kim, Jung-Hoon ^{[1
]}

Ha, Woo-Ram ^{[1
]}

Park, Jin-Hyung ^{[1
]}

Lee, Guemsan ^{[2
]}

Choi, Goya ^{[3
]}

Lee, Seung-Ho ^{[3
]}

Kim, Young-Sik ^{[4
]}

机构：

[1] Pusan Natl Univ, Sch Korean Med, Div Pharmacol, Pusan 50612, South Korea

[2] Wonkwang Univ, Coll Korean Med, Dept Herbol, Iksan 54538, Jeollabuk Do, South Korea

[3] Korea Inst Oriental Med, Daejeon 34054, South Korea

[4] Kyung Hee Univ, Coll Korean Med, Dept Herbal Pharmacol, Seoul 02447, South Korea

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2016年 / 129卷

基金：

新加坡国家研究基金会;

关键词：

Chemical interaction; Cinnamomum cassia; Paeonia lactiflora; Glycyrrhiza uralensis; Multiple regression; Marker compounds; LIQUID-CHROMATOGRAPHY; QUALITY ASSESSMENT; CORTEX CINNAMOMI; MASS-TRANSFER; CONSTITUENTS; RADIX; IDENTIFICATION; FINGERPRINT; PRINCIPLE; RUBRA;

D O I：

10.1016/j.jpba.2016.06.044

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

During decoction process, the ingredients of herbal formula interact with each other, such that therapeutic properties and chemical extraction characteristics are altered. The crude drugs, Cinnamomum cassia (CC), Paeonia lactiflora (PL), and Glycyrrhiza uralensis (GU), are the main herbal constituents of Gyeji-tang, a traditional herbal formula. To evaluate the chemical interaction between CC, PL, and GU during the course of decoction, quantification of 16 marker compounds in the herbal decoction, performed using a Box-Behnken experimental design, was carried out by HPLC-diode array detection using validated method. Correlations between the amounts of marker compounds from CC, PL, and GU were assessed by multiple regression analysis. The results obtained showed that amounts of single herb marker compounds significantly changed (usually decreased) by decoction in the presence of other herbs and that these changes depended on the chemical natures of the markers and the herbal medicines present. Results also demonstrated that the extraction efficiencies of marker compounds increased when the proportion of the herb containing them was increased and decreased in proportion to amounts of herbs added. In conclusion, chemical interactions between compositional herbal medicines may occur when herbs are co-decocted. This study provides insight of understanding the herbal interactions in herbal formulae. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：50 / 59

页数：10

共 29 条

[1]

Mass transfer process during extraction of phenolic compounds from milled berries [J].