Prion infection Seeded fibrillization or more?

被引：8

作者：

Birkmann, Eva

Riesner, Detlev ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Phys Biol, D-40225 Dusseldorf, Germany

来源：

PRION | 2008年 / 2卷 / 02期

关键词：

prion protein conversion; seeding; fibril; dimer; precursor state; kinetics; membrane;

D O I：

10.4161/pri.2.2.7060

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The prion infection is a conversion of host encoded prion protein (PrP) from its cellular isoform PrPC into the pathological and infectious isoform PrPSc; the conversion process was investigated by in vitro studies using recombinant and cellular PrP and natural PrPSc. We present a brief summary of the results determined with our in vitro conversion system and the derived mechanistic models. We describe well characterized intermediates and precursor states during the conversion process, kinetic studies of spontaneous and seeded fibrillogenesis and the impact of the membrane environment.

引用

收藏

页码：67 / 72

页数：6

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