In-vivo demonstration of dopaminergic degeneration in dementia with Lewy bodies

被引：53

作者：

Walker, Z

Costa, DC

Ince, P

McKeith, IG

Katona, CLE

机构：

[1] UCL, Sch Med, London WC1E 6BT, England

[2] Essex & Herts Community NHS Trust, Harlow, Essex, England

[3] UCL, Inst Nucl Med, London, England

[4] Newcastle Gen Hosp, Inst Hlth Elderly, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[5] Univ Newcastle Upon Tyne, Dept Neuropathol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

LANCET | 1999年 / 354卷 / 9179期

关键词：

D O I：

10.1016/S0140-6736(99)01178-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

With the dopaminergic presynaptic ligand FP-CIT and single photon emission tomography we have shown a severe dopaminergic degeneration in a patient with a necropsy confirmed diagnosis of dementia with Lewy bodies (DLB). We suggest that functional imaging of the nigrostriatal dopamine pathway helps to distinguish DLB from Alzheimer's disease during life.

引用

页码：646 / 647

页数：2

共 5 条

[1] CORE ASSESSMENT PROGRAM FOR INTRACEREBRAL TRANSPLANTATIONS (CAPIT) [J].