Synthetic regulatory RNAs as tools for engineering biological systems: Design and applications

被引：5

作者：

Seo, Sang Woo ^{[1
]}

Jung, Gyoo Yeol ^{[1
,2
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 790784, Gyeong Buk, South Korea

[2] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang 790784, Gyeong Buk, South Korea

来源：

CHEMICAL ENGINEERING SCIENCE | 2013年 / 103卷

基金：

新加坡国家研究基金会;

关键词：

Biological engineering; Biotechnology; Biochemical Engineering; Biomolecular Engineering; Synthetic biology; Synthetic RNA; IN-VIVO EVOLUTION; SECONDARY STRUCTURE; TRANSLATIONAL EFFICIENCY; NATURAL RIBOSWITCH; ESCHERICHIA-COLI; GENE-EXPRESSION; PLATFORM; RIBOREGULATORS; IDENTIFICATION; INITIATION;

D O I：

10.1016/j.ces.2013.01.017

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The engineering of biological systems requires a set of molecular tools that can be predictably applied to the design of sophisticated genetic systems. Recent advances in the held of RNA synthetic biology, particularly in the design of synthetic regulatory RNAs for the static and dynamic control of gene expression, have increased our ability to efficiently build various biological systems capable of performing programmed cellular behaviors. Furthermore, implementing these synthetic regulatory RNAs in biological systems highlights the potential for designing synthetic cell systems for chemical synthesis, environmental, agricultural, and medical applications. In this paper, we review current developments in synthetic regulatory RNAs for the static and dynamic control of gene expression and the potential applications of these tools. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：36 / 41

页数：6

共 66 条

[1] Modeling and automation of sequencing-based characterization of RNA structure [J].