Heat shock effect upon dengue virus replication into U937 cells

被引：29

作者：

Chavez-Salinas, Salvador ^{[1
]}

Ceballos-Olvera, Ivonne ^{[1
]}

Valle, Jorge Reyes-del ^{[1
]}

Medina, Fernando ^{[1
]}

del Angel, Rosa M. ^{[1
]}

机构：

[1] IPN, Ctr Invest & Estudios Avanzados, Dept Patol Expt, Mexico City 07360, DF, Mexico

来源：

VIRUS RESEARCH | 2008年 / 138卷 / 1-2期

关键词：

Lipid rafts; Hsp; Replication; Heat shock; Dengue virus;

D O I：

10.1016/j.virusres.2008.08.012

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The molecules involved in dengue virus entry into human cells are currently unknown. We have previously shown that two surface heat shock proteins (Hsps), Hsp90 and Hsp70 are part of a receptor complex in monocytic cells. In the present report, the effect of heat shock (HS) on dengue virus infection is analyzed. We have documented a more than twofold increase in dengue virus infectivity after HS treatment in monocytic cells U937; this effect correlates mainly with an increase in viral entry due to a major presence of both Hsps on the surface of monocytic cells, particularly in membrane microdomains. Interestingly, since heat shock treatment at 6 h post-infection also increased viral yields, it is likely that HS also modulates positively dengue virus replication. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：111 / 118

页数：8

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