Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

被引：47

作者：

Goto, H ^{[1
]}

Matsuo, H ^{[1
]}

Nakane, S ^{[1
]}

Izumoto, H ^{[1
]}

Fukudome, T ^{[1
]}

Kambara, C ^{[1
]}

Shibuya, N ^{[1
]}

机构：

[1] Kawatana Natl Hosp, Dept Neurol, Nagasaki 8593615, Japan

来源：

THERAPEUTIC APHERESIS | 2001年 / 5卷 / 06期

关键词：

immunomodulation; plasmapheresis; T helper type-1; T helper type-2;

D O I：

10.1046/j.1526-0968.2001.00386.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immunoadsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

引用

页码：494 / 496

页数：3

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