The Aurora/Ipi1p kinase family: regulators of chromosome segregation and cytokinesis

被引：302

作者：

Bischoff, JR ^{[1
]}

Plowman, GD ^{[1
]}

机构：

[1] SUGEN, S San Francisco, CA 94080 USA

来源：

TRENDS IN CELL BIOLOGY | 1999年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0962-8924(99)01658-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis. Proper chromosome segregation and cytokinesis ensure that each daughter cell receives the full complement of genetic material. Defects in these processes can lead to aneuploidy and the propagation of genetic abnormalities. This review discusses the Aurora/Ipl1p kinases in terms of their protein structure and proposed function in mitotic cells and also the potential role of aurora2 in human cancer.

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页码：454 / 459

页数：6

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