Magnetic Mesoporous Silica Spheres for Drug Targeting and Controlled Release

被引：86

作者：

Huang, Shanshan ^{[1
]}

Fan, Yong ^{[1
]}

Cheng, Ziyong ^{[1
]}

Kong, Deyan ^{[1
,2
]}

Yang, Piaoping ^{[3
]}

Quan, Zewei ^{[1
,2
]}

Zhang, Cuimiao ^{[1
,2
]}

Lin, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

[3] Harbin Engn Univ, Coll Mat Sci & Chem Engn, Harbin 150001, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2009年 / 113卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ASSISTED SYNTHESIS; PORE-SIZE; DELIVERY; IRON; CORE; GEL; MICROSPHERES; MCM-41; MORPHOLOGY; IBUPROFEN;

D O I：

10.1021/jp808886c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Magnetically functionalized mesoporous silica spheres with different size (average diameter, A.D.) from 150 nm to 2 mu m and pore size distribution were synthesized by generating magnetic FexOy nanoparticles onto the mesoporous silica hosts using the sol-gel method. The X-ray diffraction (XRD), field emission scanning electron microscope (FESEM), N-2 adsorption/desorption results show that these composites conserved regular sphere morphology and ordered mesoporous structure after the formation of FexOy nanoparticles. XRD and X-ray photoelectron spectroscopy (XPS) analysis confirmed that the FexOy generated in these mesoporous silica hosts is mainly composed of gamma-Fe2O3. Magnetic measurements reveal that these composites with different gamma-Fe2O3 loading amounts possess super-paramagnetic properties at 300 K, and the saturation magnetization increases with increasing Fe ratio loaded. The ibuprofen-containing spheres were then coated with biodegradable poly(DL-lactide-co-glycolide) (PLGA) by the S/O/W single-emulsion method. The PLGA hybrid magnetic spheres realize a reduced initial burst with a sustained release stage lasting for 20 days. These composites with or without the PLGA can be used as potential vectors for drug targeting and controlled-release systems.

引用

页码：1775 / 1784

页数：10

共 62 条

[1]

Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro- and mesoporous silica matrices [J].