Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research

被引：159

作者：

Carter, Christine L. ^{[1
]}

Resnick, Eileen M. ^{[1
]}

Mallampalli, Monica ^{[1
]}

Kalbarczyk, Anna ^{[1
]}

机构：

[1] Soc Womens Hlth Res, Washington, DC 20036 USA

来源：

JOURNAL OF WOMENS HEALTH | 2012年 / 21卷 / 10期

关键词：

HORMONE-THERAPY; DEMENTIA; MEN; RISK; CARE; NEUROPATHOLOGY; EDUCATION; ESTROGEN; ATROPHY; WOMEN;

D O I：

10.1089/jwh.2012.3789

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Alzheimer's disease (AD) disproportionately affects women in both prevalence and severity; however, the biologic mechanisms underlying these sex differences are not fully understood. Sex differences in the brain, such as in brain anatomy, age-related declines in brain volume, and brain glucose metabolism, have been documented and may be important in understanding AD etiology. The full impact of sex as a basic biologic variable on this neurodegenerative disease remains elusive. To address the evidence for sex differences in AD, the Society for Women's Health Research (SWHR) convened an interdisciplinary roundtable of experts from academia, clinical medicine, industry, and the government to discuss the state-of-the-science in sex and gender differences in AD. Roundtable participants were asked to address gaps in our knowledge and identify specific sex-based research questions for future areas of study.

引用

页码：1018 / 1023

页数：6

共 36 条

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Alzheimer's Disease International, 2011, WORLD ALZH REP

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