Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle

被引：94

作者：

Motrescu, Elena Roza ^{[1
]}

Rio, Marie-Christine ^{[1
]}

机构：

[1] CU Strasbourg, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM,U596,ULP,UMR 7104, F-67404 Illkirch Graffenstaden, France

来源：

BIOLOGICAL CHEMISTRY | 2008年 / 389卷 / 08期

关键词：

adipocyte-cancer cell cross-talk; adipogenesis; cancer cell survival; desmoplasia; matrix metalloproteinase 11; stromelysin; 3;

D O I：

10.1515/BC.2008.110

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment. MMP-11 negatively regulates adipogenesis by reducing pre-adipocyte differentiation and reversing mature adipocyte differentiation. Adipocyte dedifferentiation in turn leads to the accumulation of nonmalignant peritumoral fibroblast-like cells, which favor cancer cell survival and tumor progression. This MMP-11-mediated bi-directional cross-talk between invading cancer cells and adjacent adipocytes/pre-adipocytes highlights the central role that MMP-11 plays during tumor desmoplasia and represents a molecular link between obesity and cancer.

引用

页码：1037 / 1041

页数：5

共 47 条

[1]

Ahmad A, 1997, INT J CANCER, V73, P290, DOI 10.1002/(SICI)1097-0215(19971009)73:2<290::AID-IJC21>3.0.CO

[2]

2-I

[3]

Amano T, 2004, INT J MOL MED, V14, P233

[4] Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front [J].

Andarawewa, KL ;

Motrescu, ER ;

Chenard, MP ;

Gansmuller, A ;

Stoll, I ;

Tomasetto, C ;

Rio, MC .

CANCER RESEARCH, 2005, 65 (23) :10862-10871

[5]

Andarawewa KL, 2003, CANCER RES, V63, P5844

[6] EXPRESSION OF THE STROMELYSIN-3 GENE IN FIBROBLASTIC CELLS OF INVASIVE CARCINOMAS OF THE BREAST AND OTHER HUMAN TISSUES - A REVIEW [J].

BASSET, P ;

WOLF, C ;

CHAMBON, P .

BREAST CANCER RESEARCH AND TREATMENT, 1993, 24 (03) :185-193

[7] Stromelysin-3: a paradigm for stroma-derived factors implicated in carcinoma progression [J].

Basset, P ;

Bellocq, JP ;

Lefebvre, O ;

Noel, A ;

Chenard, MP ;

Wolf, C ;

Anglard, P ;

Rio, MC .

CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, 1997, 26 (01) :43-53

[8] A NOVEL METALLOPROTEINASE GENE SPECIFICALLY EXPRESSED IN STROMAL CELLS OF BREAST CARCINOMAS [J].

BASSET, P ;

BELLOCQ, JP ;

WOLF, C ;

STOLL, I ;

HUTIN, P ;

LIMACHER, JM ;

PODHAJCER, OL ;

CHENARD, MP ;

RIO, MC ;

CHAMBON, P .

NATURE, 1990, 348 (6303) :699-704

[9]

Boulay A, 2001, CANCER RES, V61, P2189

[10] Adipocyte produces matrix metalloproteinases 2 and 9 -: Involvement in adipose differentiation [J].

Bouloumié, A ;

Sengenès, C ;

Portolan, G ;

Galitzky, J ;

Lafontan, M .

DIABETES, 2001, 50 (09) :2080-2086

← 1 2 3 4 5 →