Astrocyte dysfunction in neurological disorders:: a molecular perspective

被引：599

作者：

Seifert, G

Schilling, K

Steinhäuser, C

机构：

[1] Univ Bonn, Clin Neurosurg, Dept Expt Neurobiol, D-53105 Bonn, Germany

[2] Univ Bonn, Dept Anat & Cell Biol, D-53115 Bonn, Germany

来源：

NATURE REVIEWS NEUROSCIENCE | 2006年 / 7卷 / 03期

关键词：

D O I：

10.1038/nrn1870

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent work on glial cell physiology has revealed that glial cells, and astrocytes in particular, are much more actively involved in brain information processing than previously thought. This finding has stimulated the view that the active brain should no longer be regarded solely as a network of neuronal contacts, but instead as a circuit of integrated, interactive neurons and glial cells. Consequently, glial cells could also have as yet unexpected roles in the diseased brain. An improved understanding of astrocyte biology and heterogeneity and the involvement of these cells in pathogenesis offers the potential for developing novel strategies to treat neurological disorders.

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收藏

页码：194 / 206

页数：13

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