Combination therapy with acitretin for psoriasis

被引:11
作者
Hodulik, SG [1 ]
Zeichner, JA [1 ]
机构
[1] Mt Sinai Med Ctr, Dept Dermatol, New York, NY 10029 USA
关键词
acitretin; combination therapy; psoriasis;
D O I
10.1080/09546630600632984
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Numerous therapies exist for the treatment of psoriasis. A complete understanding of the benefits and potential risks of all therapeutic options is requisite in selecting an appropriate regimen for each patient. This paper examines the effectiveness of combination therapy with acitretin in treating difficult cases of psoriasis, which may require systemic medication or phototherapy. Combination therapy is often more effective than any single agent, as medications with different mechanisms of action work synergistically. Furthermore, using lower doses of two treatments in combination can minimize the potential side effects from a single agent at a higher dose.
引用
收藏
页码:108 / 111
页数:4
相关论文
共 26 条
[1]  
*AMG, 2003, ET PACK INS
[2]  
*CONN, 2004, SOR PACK INS
[3]   Narrowband UV-B produces superior clinical and histopathological resolution of moderate-to-severe psoriasis in patients compared with broadband UV-B [J].
Coven, TR ;
Burack, LH ;
Gilleaudeau, P ;
Keogh, M ;
Ozawa, M ;
Krueger, JG .
ARCHIVES OF DERMATOLOGY, 1997, 133 (12) :1514-1522
[5]   The role of PUVA in the treatment of psoriasis: Photobiology issues related to skin cancer incidence [J].
Gasparro F.P. .
American Journal of Clinical Dermatology, 2000, 1 (6) :337-348
[6]  
*GEN INC, 2003, EF PACK INS
[7]   CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept:: Results of a randomized study [J].
Gottlieb, AB ;
Casale, TB ;
Frankel, E ;
Goffe, B ;
Lowe, N ;
Ochs, HD ;
Roberts, JL ;
Washenik, K ;
Vaishnaw, AK ;
Gordon, KB .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 49 (05) :816-825
[8]   SIDE-EFFECT PROFILE OF ACITRETIN THERAPY IN PSORIASIS [J].
GUPTA, AK ;
GOLDFARB, MT ;
ELLIS, CN ;
VOORHEES, JJ .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1989, 20 (06) :1088-1093
[9]   Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis [J].
Hoekstra, M ;
van Ede, AE ;
Haagsma, CJ ;
van de Laar, MAFJ ;
Huizinga, TWJ ;
Kruijsen, MWM ;
Laan, RFJM .
ANNALS OF THE RHEUMATIC DISEASES, 2003, 62 (05) :423-426
[10]   Cyclosporine induces cancer progression by a cell-autonomous mechanism [J].
Hojo, M ;
Morimoto, T ;
Maluccio, M ;
Asano, T ;
Morimoto, K ;
Lagman, M ;
Shimbo, T ;
Suthanthiran, M .
NATURE, 1999, 397 (6719) :530-534