Crossroads can cytoskeletal highways

被引:102
作者
Fuchs, E [1 ]
Yang, YM [1 ]
机构
[1] Univ Chicago, Howard Hughes Med Inst, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA
关键词
D O I
10.1016/S0092-8674(00)80041-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As we face the millenium, a new and more integrated view of the cytoskeleton has begun to emerge. While each cytoskeleton retains its identity, the three networks rely heavily upon one another, employing connections for cytoskeletal stability, intracellular transport and trafficking, cytokinesis, cell polarity, and tissue morphogenesis. Key genetic evidence underscores the importance of connector proteins to cytoarchitecture and structural integrity as well as many dynamic cellular processes including migration. The emergence of plakins as a vital group of linker proteins that bridge IFs, MTs, and/or MF networks has paved the entrance to a remarkable interstate of novel functional interactions among the structural elements within the cytoplasm. The discovery of actin-MT connections as well as plakins in lower eukaryotes that lack IFs, suggest that the foundations for these fascinating new cellular pathways have ancient origins.
引用
收藏
页码:547 / 550
页数:4
相关论文
共 20 条
  • [1] Not just scaffolding:: plectin regulates actin dynamics in cultured cells
    Andrä, K
    Nikolic, B
    Stöcher, M
    Drenckhahn, D
    Wiche, G
    [J]. GENES & DEVELOPMENT, 1998, 12 (21) : 3442 - 3451
  • [2] A structural scaffolding of intermediate filaments in health and disease
    Fuchs, E
    Cleveland, DW
    [J]. SCIENCE, 1998, 279 (5350) : 514 - 519
  • [3] Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage
    Gallicano, GI
    Kouklis, P
    Bauer, C
    Yin, M
    Vasioukhin, V
    Degenstein, L
    Fuchs, E
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 143 (07) : 2009 - 2022
  • [4] Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast
    Goode, BL
    Wong, JJ
    Butty, AC
    Peter, M
    McCormack, AL
    Yates, JR
    Drubin, DG
    Barnes, G
    [J]. JOURNAL OF CELL BIOLOGY, 1999, 144 (01) : 83 - 98
  • [5] kakapo, a gene required for adhesion between and within cell layers in Drosophila, encodes a large cytoskeletal linker protein related to plectin and dystrophin
    Gregory, SL
    Brown, NH
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 143 (05) : 1271 - 1282
  • [6] Formin' the connection between microtubules and the cell cortex
    Heil-Chapdelaine, RA
    Adames, NR
    Cooper, JA
    [J]. JOURNAL OF CELL BIOLOGY, 1999, 144 (05) : 809 - 811
  • [7] Direct interaction of microtubule- and actin-based transport motors
    Huang, JD
    Brady, ST
    Richards, BW
    Stenoien, D
    Resau, JH
    Copeland, NG
    Jenkins, NA
    [J]. NATURE, 1999, 397 (6716) : 267 - 270
  • [8] Targeting, capture, and stabilization of microtubules at early focal adhesions
    Kaverina, I
    Rottner, K
    Small, JV
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 142 (01) : 181 - 190
  • [9] A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of Drosophila embryos
    Lantz, VA
    Miller, KG
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 140 (04) : 897 - 910
  • [10] Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p
    Lee, L
    Klee, SK
    Evangelista, M
    Boone, C
    Pellman, D
    [J]. JOURNAL OF CELL BIOLOGY, 1999, 144 (05) : 947 - 961