CETP inhibitory activity of ceramides, isolated from the gorgonian Acabaria undulata

被引：9

作者：

Jeong, TS

Ahn, JA

Kim, YK

Bok, SH

Kwon, BM

Shin, J

Seo, Y

机构：

[1] KOREA RES INST BIOSCI & BIOTECHNOL,PROT REGULATOR RU,TAEJON 305600,SOUTH KOREA

[2] KOREA OCEAN RES & DEV INST,MARINE NAT PROD CHEM LAB,SEOUL 425600,SOUTH KOREA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(97)00248-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Four ceramides, isolated from the gorgonian Acabaria Undulata, and sphingosine analogs exhibited significant cholesteryl ester transfer protein (CETP)inhibitory activity. The ceramides 1, 2, 3, 4 and N,N-dimethylsphingosine inhibited human CETP with IC50 values of 46.8, 57.3, 86.3, 65.6 and 6.3 mu M, respectively. (C) 1997 Elsevier Science Ltd.

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收藏

页码：1481 / 1482

页数：2

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