Therapeutic Strategies Targeting Glioblastoma Stem Cells

被引：21

作者：

Carrasco-Garcia, Estefania ^{[1
]}

Sampron, Nicolas ^{[1
,2
]}

Aldaz, Paula ^{[1
]}

Arrizabalaga, Olatz ^{[1
]}

Villanua, Jorge ^{[1
,2
]}

Barrena, Cristina ^{[1
,2
]}

Ruiz, Irune ^{[1
,2
]}

Arrazola, Mariano ^{[1
,2
]}

Lawrie, Charles ^{[3
]}

Matheu, Ander ^{[1
]}

机构：

[1] Biodonostia Inst, Neurooncol Grp, E-20014 San Sebastian, Spain

[2] Donostia Hosp, Neurooncol Comm, E-20014 San Sebastian, Spain

[3] Basque Fdn Sci, Biodonostia Inst, Bilbao, Spain

来源：

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY | 2013年 / 8卷 / 03期

关键词：

Glioblastoma; glioblastoma stem cells; molecular target; therapy; TUMOR-INITIATING CELLS; GROWTH-FACTOR RECEPTOR; BRAIN-TUMORS; MALIGNANT GLIOMA; TRANSCRIPTION FACTORS; INDUCED APOPTOSIS; SOX9; EXPRESSION; SELF-RENEWAL; PTEN CONTROL; LUNG-CANCER;

D O I：

10.2174/15748928113089990002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Glioblastoma is the most common, aggressive and lethal brain tumor in adults. However, current therapeutic protocols have low success rates and average overall survival is less than 15 months. The resistance to therapy is largely a result of the remarkable cellular and phenotypical heterogeneity that characterizes this type of tumor. The discovery of a subpopulation of cells exhibiting stem cell properties within the tumor bulk has profound implications for therapy as increasing evidence indicates that these cells, glioblastoma stem cells (GSCs), are responsible for the origin, maintenance and recurrence of the glioblastomas. These findings highlight the need to characterize GSCs in order to find novel treatments directly targeted specifically against them. In this review, we summarize the current knowledge regarding this issue, including some recent and relevant patents.

引用

页码：216 / 227

页数：12

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