RB goes mitochondrial

被引：17

作者：

Attardi, Laura D. ^{[1
,2
]}

Sage, Julien ^{[2
,3
]}

机构：

[1] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

来源：

GENES & DEVELOPMENT | 2013年 / 27卷 / 09期

基金：

美国国家卫生研究院;

关键词：

MOMP; apoptosis; cancer; pRB; retinoblastoma protein; E2F1-SPECIFIC BINDING DOMAIN; P53-DEPENDENT APOPTOSIS; CELL-DEATH; RETINOBLASTOMA PROTEIN; PROAPOPTOTIC FUNCTION; UP-REGULATION; IN-VIVO; P53; E2F; PRB;

D O I：

10.1101/gad.219451.113

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The retinoblastoma tumor suppressor RB is well known for its capacity to restrict cell cycle progression at the G1/S transition of the cell cycle by controlling the transcription of cell cycle genes. In this issue of Genes & Development, Hilgendorf and colleagues (pp. 1003-1015) have identified a novel tumor suppressor function for RB independent of its role as a transcriptional regulator, in which RB directly activates the apoptosis regulator Bax at the mitochondria to promote cell death.

引用

收藏

页码：975 / 979

页数：5

相关论文

共 39 条

[1]

Phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis [J].

Adegbola, O ;

Pasternack, GR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (16) :15497-15502

[2]

p53 at a glance [J].

Brady, Colleen A. ;

Attardi, Laura D. .

JOURNAL OF CELL SCIENCE, 2010, 123 (15) :2527-2532

[3]

Cellular mechanisms of tumour suppression by the retinoblastoma gene [J].

Burkhart, Deborah L. ;

Sage, Julien .

NATURE REVIEWS CANCER, 2008, 8 (09) :671-682

[4]

P53-DEPENDENT APOPTOSIS IN THE ABSENCE OF TRANSCRIPTIONAL ACTIVATION OF P53-TARGET GENES [J].

CAELLES, C ;

HELMBERG, A ;

KARIN, M .

NATURE, 1994, 370 (6486) :220-223

[5]

DNA Damage Signals through Differentially Modified E2F1 Molecules To Induce Apoptosis [J].

Carnevale, Jasmyne ;

Palander, Oliva ;

Seifried, Laurie A. ;

Dick, Frederick A. .

MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (05) :900-912

[6]

Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb [J].

Chau, BN ;

Borges, HL ;

Chen, TT ;

Masselli, A ;

Hunton, IC ;

Wang, YJY .

NATURE CELL BIOLOGY, 2002, 4 (10) :757-765

[7]

Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma [J].

Chen, D ;

Livne-Bar, I ;

Vanderluit, JL ;

Slack, RS ;

Agochiya, M ;

Bremner, R .

CANCER CELL, 2004, 5 (06) :539-551

[8]

RB1, DEVELOPMENT, AND CANCER [J].

Chinnam, Meenalakshmi ;

Goodrich, David W. .

CANCER AND DEVELOPMENT, 2011, 94 :129-169

[9]

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53 [J].

Chipuk, JE ;

Bouchier-Hayes, L ;

Kuwana, T ;

Newmeyer, DD ;

Green, DR .

SCIENCE, 2005, 309 (5741) :1732-1735

[10]

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis [J].

Chipuk, JE ;

Kuwana, T ;

Bouchier-Hayes, L ;

Droin, NM ;

Newmeyer, D ;

Schuler, M ;

Green, DR .

SCIENCE, 2004, 303 (5660) :1010-1014

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