ADA-bypass by lipophilic cycloSal-ddAMP pro-nucleotides a second example of the efficiency of the cycloSal-concept

被引：34

作者：

Meier, C ^{[1
]}

Knispel, T ^{[1
]}

DeClercq, E ^{[1
]}

Balzarini, J ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(97)00265-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of lipophilic pro-nucleotides of ddAMP 2 based on cycloSal-ddAMP 3a-c is described. Phosphotriesters 3 released ddAMP 2 selectively by a controlled, chemically induced tandem reaction. CycloSal-phosphotriesters 3 exhibited antiviral activity against HIV-1/HIV-2 in CEM cells that where by a factor up to hundred higher as compared to ddA 1. (C) 1997 Elsevier Science Ltd.

引用

页码：1577 / 1582

页数：6

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