Potassium channel blockade does not alter the modulatory effects of dopamine in neostriatal slices

被引：5

作者：

Altemus, KL ^{[1
]}

Levine, MS ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR,LOS ANGELES,CA 90024

来源：

BRAIN RESEARCH | 1996年 / 718卷 / 1-2期

关键词：

depolarizing postsynaptic potential; dopamine; 4-aminopyridine; cesium; tetraethylammonium;

D O I：

10.1016/0006-8993(96)00124-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study assessed the contribution of Iii conductances to dopamine (DA)-induced modulation of evoked depolarizing synaptic responses (DPSPs) in neostriatal slices obtained from mts. Intracellular recordings of membrane properties and DPSPs evoked by local electrical stimulation were obtained from cells bathed in standard artificial cerebrospinal fluid (ACSF), 5 mM Cs- + in ACSF, 20 mM tetraethylammonium in ACSF, or 1 mM 4-aminopyridine in ACSF. DA altered response amplitude in approximately equal proportions regardless of the presence or abscence of these K+-channel blockers. These findings suggest that K+ conductances do not provide a major contribution ro DA-induced changes in DPSPs in the neostriatum.

引用

页码：212 / 216

页数：5

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