Macrophage defences against respiratory tract infections

被引：179

作者：

Gordon, SB

Read, RC ^{[1
]}

机构：

[1] Univ Sheffield, Royal Hallamshire Hosp, Div Gneom Med, Med Sch, Sheffield S10 2RX, S Yorkshire, England

[2] Univ Malawi, Wellcome Trust Res Labs, Queen Elizabeth Cent Hosp, Blantyre, Malawi

[3] Univ Liverpool, Wellcome Trust Res Labs, Queen Elizabeth Cent Hosp, Blantyre, Malawi

来源：

BRITISH MEDICAL BULLETIN | 2002年 / 61卷

关键词：

D O I：

10.1093/bmb/61.1.45

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Pulmonary macrophages with a key role in defence against respiratory infection are a heterogeneous family of cells with phagocytic, antigen processing and immunomodulatory functions. Macrophages are important in both innate and acquired immunity in the respiratory tract, and have a role in lung defence against viruses, bacteria, mycobacteria and fungi. Interactions of pathogens with lung macrophages is strongly influenced by soluble immune components including complement, collectins and immunoglobulins. Macrophage function can be modulated by cytokines, environmental exposures, recent and chronic infection including HIV infection, drug therapy and gene transfer.

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页码：45 / 61

页数：17

相关论文

共 69 条

[1]

Toll-like receptors in the induction of the innate immune response [J].

Aderem, A ;

Ulevitch, RJ .

NATURE, 2000, 406 (6797) :782-787

[2]

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection [J].

Altare, F ;

Lammas, D ;

Revy, P ;

Jouanguy, E ;

Döffinger, R ;

Lamhamedi, S ;

Drysdale, P ;

Scheel-Toellner, D ;

Girdlestone, J ;

Darbyshire, P ;

Wadhwa, M ;

Dockrell, H ;

Salmon, M ;

Fischer, A ;

Durandy, A ;

Casanova, JL ;

Kumararatne, DS .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (12) :2035-2040

[3]

Balcewicz-Sablinska MK, 1998, J IMMUNOL, V161, P2636

[4]

Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice [J].

Bergeron, Y ;

Ouellet, N ;

Deslauriers, AM ;

Simard, M ;

Olivier, M ;

Bergeron, MG .

INFECTION AND IMMUNITY, 1998, 66 (03) :912-922

[5]

Pulmonary immune memory: Localized production of antibody in the lung after antigen challenge [J].

Bice, DE ;

Muggenburg, BA .

IMMUNOLOGY, 1996, 88 (02) :191-197

[6]

Human alveolar macrophages induce functional inactivation in antigen-specific CD4 T cells [J].

Blumenthal, RL ;

Campbell, DE ;

Hwang, P ;

DeKruyff, RH ;

Frankel, LR ;

Umetsu, DT .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (02) :258-264

[7]

INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) IS UP-REGULATED ON ALVEOLAR MACROPHAGES FROM AIDS PATIENTS [J].

BOHNET, S ;

BRAUN, J ;

DALHOFF, K .

EUROPEAN RESPIRATORY JOURNAL, 1994, 7 (02) :229-234

[8]

Brieland JK, 1996, J IMMUNOL, V157, P5002

[9]

Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: Elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival [J].

BrougHolub, E ;

Toews, GB ;

VanIwaarden, JF ;

Strieter, RM ;

Kunkel, L ;

Paine, R ;

Standiford, TJ .

INFECTION AND IMMUNITY, 1997, 65 (04) :1139-1146

[10]

Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense [J].

Chen, GH ;

Reddy, RC ;

Newstead, MW ;

Tateda, K ;

Kyasapura, BL ;

Standiford, TJ .

JOURNAL OF IMMUNOLOGY, 2000, 165 (11) :6496-6503

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