Protein modifications in transcription elongation

被引：53

作者：

Fuchs, Stephen M. ^{[2
]}

Laribee, R. Nicholas ^{[3
]}

Strahl, Brian D. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ Tennessee, Hlth Sci Ctr, Dept Pathol & Lab Med, Memphis, TN 38163 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2009年 / 1789卷 / 01期

关键词：

Posttranslational modification; Histone; Transcription; RNA polymerase II; Chromatin; RNA-POLYMERASE-II; C-TERMINAL DOMAIN; CHROMATIN-REMODELING COMPLEX; HISTONE H2B UBIQUITYLATION; REGULATES H3 METHYLATION; SACCHAROMYCES-CEREVISIAE; LYSINE-4; METHYLATION; ARGININE METHYLATION; PHD FINGER; DNA-DAMAGE;

D O I：

10.1016/j.bbagrm.2008.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Posttranslational modifications (PTMs) of proteins play essential roles in regulating signaling, protein-protein modifications and subcellular localization. In this review, we focus on posttranslational modification of histones and RNA polymerase II (RNAPII) and their roles in gene transcription. A survey of the basic features of PTMs is provided followed by a more detailed account of how PTMs on histones and RNAPII regulate transcription in the model organism Saccharomyces cerevisiae. We emphasize the interconnections between histone and RNAPII PTMs and speculate upon the larger role PTMs have in regulating protein function in the cell. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：26 / 36

页数：11

共 193 条

[1] H2B (Ser10) phosphorylation is induced during apoptosis and meiosis in S-cerevisiae [J].

Ahn, SH ;

Henderson, KA ;

Keeney, S ;

Allis, CD .

CELL CYCLE, 2005, 4 (06) :780-783

[2] Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae [J].

Ahn, SH ;

Cheung, WL ;

Hsu, JY ;

Diaz, RL ;

Smith, MM ;

Allis, CD .

CELL, 2005, 120 (01) :25-36

[3] Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10 [J].

Ahn, Sung-Hee ;

Diaz, Robert L. ;

Grunstein, Michael ;

Allis, C. David .

MOLECULAR CELL, 2006, 24 (02) :211-220

[4] STRUCTURAL MODIFICATIONS OF HISTONES + THEIR POSSIBLE ROLE IN REGULATION OF RNA SYNTHESIS [J].

ALLFREY, VG ;

MIRSKY, AE .

SCIENCE, 1964, 144 (361) :559-&

[5] ACETYLATION + METHYLATION OF HISTONES + THEIR POSSIBLE ROLE IN REGULATION OF RNA SYNTHESIS [J].

ALLFREY, VG ;

FAULKNER, R ;

MIRSKY, AE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (05) :786-+

[6] New nomenclature for chromatin-modifying enzymes [J].

Allis, C. David ;

Berger, Shelley L. ;

Cote, Jacques ;

Dent, Sharon ;

Jenuwien, Thomas ;

Kouzarides, Tony ;

Pillus, Lorraine ;

Reinberg, Danny ;

Shi, Yang ;

Shiekhattar, Ramin ;

Shilatifard, Ali ;

Workman, Jerry ;

Zhang, Yi .

CELL, 2007, 131 (04) :633-636

[7] A role for the CPF 3′-end processing machinery in RNAP II-dependent gene looping [J].

Ansari, A ;

Hampsey, M .

GENES & DEVELOPMENT, 2005, 19 (24) :2969-2978

[8] The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion [J].

Baetz, KK ;

Krogan, NJ ;

Emili, A ;

Greenblatt, J ;

Hieter, P .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (03) :1232-1244

[9] Arginine methylation: An emerging regulator of protein function [J].

Bedford, MT ;

Richard, S .

MOLECULAR CELL, 2005, 18 (03) :263-272

[10] The complex language of chromatin regulation during transcription [J].

Berger, Shelley L. .

NATURE, 2007, 447 (7143) :407-412

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