Under Pressure: Mechanical Stress Management in the Nucleus

被引：42

作者：

Belaadi, Nejma ^{[1
]}

Aureille, Julien ^{[2
]}

Guilluy, Christophe ^{[2
]}

机构：

[1] Univ Nantes, Inst Natl Sante & Rech Med, Inst Thorax, CNRS,UMR 6291,UMR 1087, F-44000 Nantes, France

[2] Univ Grenoble Alpes, Inst Natl Sante & Rech Med, Inst Adv Biosci, CNRS UMR 5309,UMR 1209, F-38041 Grenoble, France

来源：

CELLS | 2016年 / 5卷 / 02期

基金：

欧洲研究理事会;

关键词：

mechanotransduction; nucleoskeleton; lamina; lamin; LINC; nucleus; mechanical stress; MEMBRANE PROTEIN; LINC COMPLEX; SUN PROTEINS; EXTRACELLULAR-MATRIX; CADHERIN JUNCTIONS; CELL-MIGRATION; ACTIN FLOW; LAMIN A/C; ENVELOPE; NESPRIN-2;

D O I：

10.3390/cells5020027

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms. Whereas adhesion structures have been shown to play a central role in mechanotransduction, it now emerges that the nucleus may act as a mechanosensitive structure. Here, we review recent advances demonstrating that mechanical stress emanating from the cytoskeleton can activate pathways in the nucleus which eventually impact both its structure and the transcriptional machinery.

引用

页数：11

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[2]

Antoku S., 2015, CELL CYCLE

[3]

Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension [J].