Biodegradable scleral plugs for vitreoretinal drug delivery

被引:84
作者
Yasukawa, T
Kimura, H
Tabata, Y
Ogura, Y
机构
[1] Kyoto Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Sakyo Ku, Kyoto 6068507, Japan
[2] Nagoya City Univ, Sch Med, Dept Ophthalmol, Mizuho Ku, Nagoya, Aichi 4678601, Japan
[3] Kyoto Univ, Inst Frontier Med Sci, Kyoto 6068507, Japan
关键词
biodegradable polymer; cytomegalovirus retinitis; intraocular controlled release; poly(DL-lactide); poly(DL-lactide-co-glycolide); scleral implant;
D O I
10.1016/S0169-409X(01)00192-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Intraocular controlled drug release is one way to facilitate drug efficacy and decrease side effects that occur with systemic administration. Vitreoretinal drug delivery with the biodegradable scleral plug has been investigated. The scleral plug, which is made of biodegradable polymers and drugs, can be implanted at the pats plana using a simple procedure, and it gradually releases effective doses of drugs with polymer biodegradation for several months. The release profiles of the drugs were dependent on the hind of polymers used, their molecular weights, and the amount of drug in the plug. The plugs are effective for treating vitreoretinal diseases such as proliferative vitreoretinopathy. The implantation site was replaced with connective tissue. Electroretinography and histologic studies revealed little retinal toxicity. This implantable scleral plug was supposed to be advantageous for diseases such as cytomegalovirus retinitis that respond to repeated intravitreal injections and for vitreoretinal disorders that require vitrectomy. (C) 2001 Elsevier Science B V All rights reserved.
引用
收藏
页码:25 / 36
页数:12
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