Zidovudine therapy protects against Salmonella bacteremia recurrence in human immunodeficiency virus-infected patients

被引:27
作者
Casado, JL
Valdezate, S
Calderon, C
Navas, E
Frutos, B
Guerrero, A
Martinez-Beltran, J
机构
[1] Hosp Ramon y Cajal, Infect Dis Unit, E-28034 Madrid, Spain
[2] Hosp Ramon y Cajal, Dept Microbiol, E-28034 Madrid, Spain
关键词
D O I
10.1086/314749
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Fifty-five human immunodeficiency virus-infected patients with Salmonella bacteremia were studied to assess the rate of and causes for recurrence and to determine the influence on relapse of zidovudine, cotrimoxazole, and antimicrobial suppressive therapy according to the susceptibility of the isolates. Overall, 22% of patients relapsed in a median time of 87 days, independent of CD4 cell count, Salmonella serotype, or duration of antibiotic therapy. The use of zidovudine was associated with the lowest rate of recurrences compared with cotrimoxazole or amoxicillin as suppressive therapy. In the microbiologic assay, zidovudine showed bactericidal effect on Salmonella species at current dosages, and resistance to zidovudine was uncommon (2 cases, 4%). Due to its direct effect on Salmonella species, a zidovudine-containing regimen may protect against the recurrence of the disease.
引用
收藏
页码:1553 / 1556
页数:4
相关论文
共 14 条
[1]  
CARRILLO CS, 1996, J ANTIMICROB CHEMOTH, V38, P153
[2]   ANTIBACTERIAL ACTIVITY AND MECHANISM OF ACTION OF 3'-AZIDO-3'-DEOXYTHYMIDINE (BW-A509U) [J].
ELWELL, LP ;
FERONE, R ;
FREEMAN, GA ;
FYFE, JA ;
HILL, JA ;
RAY, PH ;
RICHARDS, CA ;
SINGER, SC ;
KNICK, VB ;
RIDEOUT, JL ;
ZIMMERMAN, TP .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (02) :274-280
[3]  
FARMER JJ, 1990, MANUAL CLIN MICROBIO, P360
[4]  
Fischman DA, 1986, MYOLOGY, V1, P5
[5]   RECURRENT SALMONELLA-TYPHIMURIUM BACTEREMIA ASSOCIATED WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].
GLASER, JB ;
MORTONKUTE, L ;
BERGER, SR ;
WEBER, J ;
SIEGAL, FP ;
LOPEZ, C ;
ROBBINS, W ;
LANDESMAN, SH .
ANNALS OF INTERNAL MEDICINE, 1985, 102 (02) :189-193
[6]   SALMONELLA INFECTIONS IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].
JACOBS, JL ;
GOLD, JWM ;
MURRAY, HW ;
ROBERTS, RB ;
ARMSTRONG, D .
ANNALS OF INTERNAL MEDICINE, 1985, 102 (02) :186-188
[7]   ZIDOVUDINE-RESISTANCE IN SALMONELLA-TYPHIMURIUM AND ESCHERICHIA-COLI [J].
LEWIN, CS ;
ALLEN, R ;
AMYES, SGB .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 (04) :706-708
[8]   CONDITIONS REQUIRED FOR THE ANTIBACTERIAL ACTIVITY OF ZIDOVUDINE [J].
LEWIN, CS ;
AMYES, SGB .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1989, 8 (08) :737-741
[9]   SALMONELLA BACTEREMIA ASSOCIATED WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) [J].
NADELMAN, RB ;
MATHURWAGH, U ;
YANCOVITZ, SR ;
MILDVAN, D .
ARCHIVES OF INTERNAL MEDICINE, 1985, 145 (11) :1968-1971
[10]  
National Committee for Clinical Laboratory Standards, 1993, M7A3 NCCLS, V13, P25, DOI DOI 10.1016/J.BMC.2008.11.008