Impact of Cigarette Smoking on Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

被引：125

作者：

Agudo, Antonio ^{[1
]}

Bonet, Catalina ^{[1
]}

Travier, Noemie ^{[1
]}

Gonzalez, Carlos A. ^{[1
]}

Vineis, Paolo ^{[8
,13
]}

Bueno-de-Mesquita, H. Bas ^{[17
,18
]}

Trichopoulos, Dimitrios ^{[19
,22
]}

Boffetta, Paolo ^{[20
,21
,25
]}

Clavel-Chapelon, Francoise ^{[27
,28
]}

Boutron-Ruault, Marie-Christine ^{[27
,28
]}

Kaaks, Rudolf ^{[29
]}

Lukanova, Annekatrin ^{[29
]}

Schuetze, Madlen ^{[30
]}

Boeing, Heiner ^{[30
]}

Tjonneland, Anne ^{[31
]}

Halkjaer, Jytte ^{[31
]}

Overvad, Kim ^{[32
]}

Dahm, Christina C. ^{[32
]}

Ramon Quiros, J. ^{[2
]}

Sanchez, Maria-Jose ^{[3
,4
]}

Larranaga, Nerea ^{[4
,5
]}

Navarro, Carmen ^{[4
,6
]}

Ardanaz, Eva ^{[4
,7
]}

Khaw, Kay-Tee ^{[14
]}

Wareham, Nicholas J. ^{[15
]}

Key, Timothy J. ^{[16
]}

Allen, Naomi E. ^{[16
]}

Trichopoulou, Antonia ^{[23
,24
]}

Lagiou, Pagona ^{[19
,23
]}

Palli, Domenico ^{[9
]}

Sieri, Sabina ^{[10
]}

Tumino, Rosario ^{[11
]}

Panico, Salvatore ^{[12
]}

Boshuizen, Hendriek ^{[17
]}

Buchner, Frederike L. ^{[17
]}

Peeters, Petra H. M. ^{[18
]}

Borgquist, Signe ^{[33
]}

Almquist, Martin ^{[33
]}

Hallmans, Goran ^{[34
]}

Johansson, Ingegerd ^{[34
]}

Gram, Inger T. ^{[36
]}

Lund, Eiliv ^{[36
]}

Weiderpass, Elisabete ^{[35
,36
,37
,38
]}

Romieu, Isabelle ^{[26
]}

Riboli, Elio ^{[13
]}

机构：

[1] Catalan Inst Oncol, IDIBELL, Barcelona, Spain

[2] Publ Hlth & Planning Directorate, Asturias, Spain

[3] Andalusian Sch Publ Hlth, Granada, Spain

[4] CIBER Epidemiol & Publ Hlth, Madrid, Spain

[5] Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[6] NE Thames Reg Hlth Author, Murcia, Spain

[7] Navarre Publ Hlth Inst, Pamplona, Spain

[8] Inst Sci Interchange Fdn, Turin, Italy

[9] Canc Res & Prevent Inst, Florence, Italy

[10] Fdn IRCCS Ist Nazl Tumori, Milan, Italy

[11] Civile MP Arezzo Hosp, Ragusa, Italy

[12] Univ Naples Federico II, Naples, Italy

[13] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[14] Univ Cambridge, Cambridge, England

[15] MRC Epidemiol Unit, Cambridge, England

[16] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[17] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[18] Univ Med Ctr, Utrecht, Netherlands

[19] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[20] Mt Sinai Sch Med, Inst Translat Epidemiol, New York, NY USA

[21] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA

[22] Acad Athens, Bur Epidemiol Res, Athens, Greece

[23] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[24] Hellen Hlth Fdn, Athens, Greece

[25] Int Prevent Res Inst, Lyon, France

[26] Int Agcy Res Canc, F-69372 Lyon, France

[27] Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, Villejuif, France

[28] Paris S Univ, Villejuif, France

[29] German Canc Res Ctr, D-6900 Heidelberg, Germany

[30] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany

[31] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[32] Aarhus Univ, Aarhus, Denmark

[33] Lund Univ, Lund, Sweden

[34] Umea Univ, Umea, Sweden

[35] Karolinska Inst, Stockholm, Sweden

[36] Univ Tromso, Inst Community Med, Tromso, Norway

[37] Canc Registry Norway, Oslo, Norway

[38] Samfundet Folkhalsan, Helsinki, Finland

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2012年 / 30卷 / 36期

基金：

英国惠康基金; 瑞典研究理事会; 英国医学研究理事会;

关键词：

TOBACCO SMOKING;

D O I：

10.1200/JCO.2011.41.0183

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC). Methods The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AF(p)), calculated using the adjusted hazard ratios and 95% CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country. Results The proportion of all TRC attributable to cigarette smoking was 34.9% (95% CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2% (95% CI, 33.7 to 38.6) using the smoking prevalence from the population. The AF(p) were above 80% for cancers of the lung and larynx, between 20% and 50% for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20% for the remaining TRC. Conclusion Using data on cancer incidence for 2008 and our AF(p) estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark). J Clin Oncol 30:4550-4557. (C) 2012 by American Society of Clinical Oncology

引用

页码：4550 / 4557

页数：8

共 26 条

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