Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You

被引：45

作者：

Carroll, Richard G. ^{[1
]}

Martin, Seamus J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Smurfit Inst, Dept Genet, Mol Cell Biol Lab, Dublin 2, Ireland

来源：

CANCER CELL | 2013年 / 23卷 / 04期

关键词：

CELL-DEATH;

D O I：

10.1016/j.ccr.2013.04.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Autophagy, a process for recycling cellular constituents, is normally associated with cell survival and is thought to be beneficial for tumor maintenance. However, in this issue of Cancer Cell, Lamy and colleagues report that multiple myeloma utilizes caspase-10 to restrain autophagy and undergoes autophagic cell death upon its removal or inhibition.

引用

页码：425 / 426

页数：2

共 10 条

[1]

DangER: protein ovERload. Targeting protein degradation to treat myeloma [J].

Aronson, Lauren I. ;

Davies, Faith E. .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (08) :1119-1130

[2]

Choi AMK, 2013, NEW ENGL J MED, V368, P1845, DOI [10.1056/NEJMra1205406, 10.1056/NEJMc1303158]

[3]

Das G., 2012, COLD SPRING HARB PER, V4, DOI [10.1101/cshperspect.a008813, DOI 10.1101/CSHPERSPECT.A008813]

[4]

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival [J].

Elgendy, Mohamed ;

Sheridan, Clare ;

Brumatti, Gabriela ;

Martin, Seamus J. .

MOLECULAR CELL, 2011, 42 (01) :23-35

[5]

Effect of autophagy on multiple myeloma cell viability [J].

Hoang, Bao ;

Benavides, Angelica ;

Shi, Yijiang ;

Frost, Patrick ;

Lichtenstein, Alan .

MOLECULAR CANCER THERAPEUTICS, 2009, 8 (07) :1974-1984

[6]

Autophagic cell death: the story of a misnomer [J].

Kroemer, Guido ;

Levine, Beth .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (12) :1004-1010

[7]

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma [J].

Lamy, Laurence ;

Ngo, Vu N. ;

Emre, N. C. Tolga ;

Shaffer, Arthur L., III ;

Yang, Yandan ;

Tian, Erming ;

Nair, Vinod ;

Kruhlak, Michael J. ;

Zingone, Adriana ;

Landgren, Ola ;

Staudt, Louis M. .

CANCER CELL, 2013, 23 (04) :435-449

[8]

Compromising the Unfolded Protein Response Induces Autophagy-Mediated Cell Death in Multiple Myeloma Cells [J].

Michallet, Anne-Sophie ;

Mondiere, Paul ;

Taillardet, Morgan ;

Leverrier, Yann ;

Genestier, Laurent ;

Defrance, Thierry .

PLOS ONE, 2011, 6 (10)

[9]

Plasma cells require autophagy for sustainable immunoglobulin production [J].

Pengo, Niccolo ;

Scolari, Maria ;

Oliva, Laura ;

Milan, Enrico ;

Mainoldi, Federica ;

Raimondi, Andrea ;

Fagioli, Claudio ;

Merlini, Arianna ;

Mariani, Elisabetta ;

Pasqualetto, Elena ;

Orfanelli, Ugo ;

Ponzoni, Maurilio ;

Sitia, Roberto ;

Casola, Stefano ;

Cenci, Simone .

NATURE IMMUNOLOGY, 2013, 14 (03) :298-305

[10]

Deconvoluting the context-dependent role for autophagy in cancer [J].

White, Eileen .

NATURE REVIEWS CANCER, 2012, 12 (06) :401-410

← 1 →