Sarcopenia: Pharmacology of Today and Tomorrow

被引:52
作者
Brotto, Marco [1 ]
Abreu, Eduardo L.
机构
[1] Univ Missouri, Muscle Biol Res Grp MUBIG, Sch Nursing, Kansas City, MO 64108 USA
基金
美国国家卫生研究院;
关键词
SKELETAL-MUSCLE ATROPHY; OPERATED CA2+ ENTRY; HANDGRIP STRENGTH; PHYSICAL FUNCTION; GROWTH-HORMONE; MESSENGER-RNA; EXERCISE; DEHYDROEPIANDROSTERONE; SUPPLEMENTATION; ACTIVATION;
D O I
10.1124/jpet.112.191759
中图分类号
R9 [药学];
学科分类号
100702 [药剂学];
摘要
Sarcopenia remains largely undiagnosed and undertreated because of the lack of a universally accepted definition, effective ways to measure it, and identification of the outcomes that should guide treatment efficacy. An ever-growing number of clinicians and researchers along with funding and regulatory agencies have gradually recognized that sarcopenia is a human condition that requires both prevention and treatment. In this article, we review sarcopenia and its common and less known pharmacological treatments, attempt to define sarcopenia in its broader context, and present some new ideas for potential future treatment for this devastating condition.
引用
收藏
页码:540 / 546
页数:7
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