Synthesis and biological activity of side-chain analogues of ecdysone and 20-hydroxyecdysone

被引：20

作者：

Roussel, PG

Sik, V

Turner, NJ

Dinan, LN

机构：

[1] UNIV EXETER, DEPT CHEM, EXETER EX4 4QD, DEVON, ENGLAND

[2] UNIV EXETER, WASHINGTON SINGER LABS, DEPT BIOL SCI, EXETER EX4 4QG, DEVON, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 15期

关键词：

D O I：

10.1039/a700986k

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Side-chain analogues of 20-hydroxyecdysone 1 and ecdysone 2 containing a tetrahydrofuran ring, including shidasterone 4, have been prepared and assessed for biological activity using a bioassay derived from a tumorous B-II blood cell line of Drosophila melanogaster, The synthetic strategy involves selective protection of the 2,3-cis-diol of 1 and 2 followed by activation of the C-22 hydroxy group prior to ring-closure.

引用

页码：2237 / 2246

页数：10

共 18 条

[1]

SOME STEREOSELECTIVE AND REGIOSELECTIVE OLEFIN ADDITIONS - IODOACETOXYLATION AND RELATED ELECTROPHILIC ADDITIONS ACROSS 22(23)-BOND OF 3-ALPHA,5-ALPHA-CYCLOERGOSTA-7,22-DIEN-6-ONE [J].