IL-6 cytokine family and signal transduction: A model of the cytokine system

被引：190

作者：

Hibi, M ^{[1
]}

Nakajima, K ^{[1
]}

Hirano, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,BIOMED RES CTR,SUITA,OSAKA 565,JAPAN

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1996年 / 74卷 / 01期

关键词：

IL-6; family; cytokine; gp130; JAK; STAT; signal transduction;

D O I：

10.1007/BF00202068

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The interleukin 6 (IL-6) cytokine family, which includes IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), IL-11 and cardiotrophin-1 (CT-1), exhibits pleiotropy and redundancy in biological. activities. The IL-6 family cytokines exhibit a helical structure. Their receptors belong to the type 1 cytokine receptor family. The receptors of the IL-6 family cytokines share a receptor subunit, which explains one of the mechanisms of functional redundancy. In this review, we describe the general features of the IL-6 cytokine family and its signal transduction mechanisms. Many functional properties of the IL-6 family of cytokines and their receptors are general features of the cytokine system.

引用

页码：1 / 12

页数：12

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