Tumor necrosis factor-α and interleukin-1α decrease the adherence of Streptococcus pyogenes to cultured keratinocytes

被引:10
作者
Darmstadt, GL
Fleckman, P
Rubens, CE
机构
[1] Univ Washington, Sch Med, Div Infect Dis, Dept Pediat CH 32,Childrens Hosp & Reg Med Ctr, Seattle, WA 98105 USA
[2] Univ Washington, Sch Med, Div Dermatol, Dept Pediat CH 32,Childrens Hosp & Reg Med Ctr, Seattle, WA 98105 USA
关键词
D O I
10.1086/315066
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We hypothesized that the primary epidermal cytokines, tumor necrosis factor (TNF)-alpha and interleukin (TL)-1 alpha, which are produced after skin injury, modulate bacterial adherence and the initiation of group A streptococcal skin infections. Streptococcus pyogenes binds preferentially to highly differentiated keratinocytes in vitro, simulating the superficial human skin infection, impetigo, and providing a model system for testing this hypothesis. Exposure of keratinocytes to 10 ng/mL TNF-alpha for 20 h decreased adherence to undifferentiated and differentiated keratinocytes by 33% and 38%, respectively. Treatment with 1 ng/mL IL-1 alpha decreased adherence to undifferentiated and differentiated keratinocytes by 23% and 18%, respectively. Exposure to both cytokines simultaneously produced an additive 50% reduction in adherence. These data suggest that TNF-alpha and IL-1 alpha may play a role in cutaneous host defense by impeding streptococcal adherence and decreasing its ability to form a nidus of infection in the skin.
引用
收藏
页码:1718 / 1721
页数:4
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