Dermal-resident CD14+ cells:: differentiate into Langerhans cells

被引:172
作者
Larregina, AT [1 ]
Morelli, AE
Spencer, LA
Logar, AJ
Watkins, SC
Thomson, AW
Falo, LD
机构
[1] Univ Pittsburgh, Med Ctr, Dept Dermatol, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Med Ctr, Pittsburgh Canc Inst, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Med Ctr, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15213 USA
[4] Univ Pittsburgh, Med Ctr, Dept Surg, Pittsburgh, PA 15213 USA
[5] Univ Pittsburgh, Med Ctr, Dept Physiol, Pittsburgh, PA 15213 USA
[6] Univ Pittsburgh, Med Ctr, Ctr Biol Imaging, Pittsburgh, PA 15213 USA
关键词
D O I
10.1038/ni731
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Epidermal Langerhans cells (LCs) show extraordinary immunostimulatory capacity and play a key role in the initiation and regulation of immune responses. Studies of LC biology are currently the focus of efforts to engineer immune responses and to better understand the immunopathology of cutaneous diseases. Here we identified and characterized a population of LC precursors that were resident in human skin. These immediate precursors expressed CD14, langerin and functional CCR6. When cultured with transforming growth factor-beta1 alone, they had the potential to differentiate into epidermal LCs; when cultured in the presence of granulocyte macrophage-colony-stimulating factor and interleukin 4 they differentiated into functionally mature dendritic cells. Identification and characterization of these LC precursors provided insight into LC biology and the mechanism(s) through which LCs repopulate the epidermis.
引用
收藏
页码:1151 / 1158
页数:8
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