Innate lymphoid cells - a proposal for uniform nomenclature

被引：1877

作者：

Spits, Hergen ^{[1
]}

Artis, David ^{[2
,3
]}

Colonna, Marco ^{[4
]}

Diefenbach, Andreas ^{[5
]}

Di Santo, James P. ^{[6
]}

Eberl, Gerard ^{[7
]}

Koyasu, Shigeo ^{[8
,9
]}

Locksley, Richard M. ^{[10
]}

McKenzie, Andrew N. J. ^{[11
]}

Mebius, Reina E. ^{[12
]}

Powrie, Fiona ^{[13
]}

Vivier, Eric ^{[14
,15
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, NL-1105 BK Amsterdam, Netherlands

[2] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[5] Univ Freiburg, Inst Med Microbiol & Hyg, D-79104 Freiburg, Germany

[6] Inst Pasteur, Innate Immun Unit, F-75724 Paris, France

[7] Inst Pasteur, Dev Lymphoid Tissues Unit, F-75724 Paris, France

[8] CREST, Dept Microbiol & Immunol, Chiyoda Ku, Tokyo 1020075, Japan

[9] RIKEN, Res Ctr Allergy & Immunol, Lab Immune Cell Syst, Yokohama, Kanagawa 2300045, Japan

[10] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[11] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

[12] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, NL-1007 MB Amsterdam, Netherlands

[13] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Translat Gastroenterol Unit, Oxford OX3 9DU, England

[14] INSERM, U1104, Ctr Immunol Marseille Luminy, F-13009 Marseille, France

[15] CNRS, UMR7280, F-13288 Marseille, France

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

TRANSCRIPTION FACTOR GATA3; TISSUE-INDUCER CELLS; NATURAL-KILLER-CELLS; ROR-GAMMA-T; LUNG; EXPRESSION; INFECTION; CYTOKINES; DISTINCT; FAMILY;

D O I：

10.1038/nri3365

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphoid cells (ILCs) are a family of developmentally related cells that are involved in immunity and in tissue development and remodelling. Recent research has identified several distinct members of this family. Confusingly, many different names have been used to characterize these newly identified ILC subsets. Here, we propose that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function.

引用

页码：145 / 149

页数：5

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