Short and efficient preparations of isoxazole-3-carboxylic acid and imino-oxopentanoic acid potent precursors of 4-hydroxyisoleucine

被引：10

作者：

Becht, JM ^{[1
]}

Marin, SD ^{[1
]}

Maruani, M ^{[1
]}

Wagner, A ^{[1
]}

Mioskowski, C ^{[1
]}

机构：

[1] Univ Strasbourg 1, Fac Pharm, CNRS, Lab Synth Bioorgan,UMR 7514, F-67400 Illkirch Graffenstaden, France

来源：

TETRAHEDRON | 2006年 / 62卷 / 18期

关键词：

achiral precursors; organic phase; stereoselective;

D O I：

10.1016/j.tet.2006.02.056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we describe short and efficient syntheses of isoxazole-3-carboxylic acid 3a and imino-oxopentanoic acid 8 achiral precursors of 4-hydroxyisoleucine. The developed procedures involve readily available and cheap starting materials and can easily be transposed to the large scale. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4430 / 4434

页数：5

共 11 条

[1] OXIDATION OF VICINAL DIOLS TO ALPHA-DICARBONYL COMPOUNDS BY TRIFLUOROACETIC-ANHYDRIDE ACTIVATED DIMETHYLSULFOXIDE [J].