Prognostic value of histopathological therapeutic effects and mitotic index in locally advanced breast cancers after neoadjuvant chemotherapy

被引：7

作者：

AkashiTanaka, S ^{[1
]}

Tsuda, H ^{[1
]}

Fukuda, H ^{[1
]}

Watanabe, T ^{[1
]}

Fukutomi, T ^{[1
]}

机构：

[1] NATL CANC CTR,DEPT SURG ONCOL,CHUO KU,TOKYO 104,JAPAN

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 1996年 / 26卷 / 04期

关键词：

locally advanced breast cancer; neoadjuvant chemotherapy; prognostic factor; mitotic index; therapeutic effect;

D O I：

10.1093/oxfordjournals.jjco.a023214

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A study was conducted to examine whether or not the histopathological therapeutic effects of preoperative chemotherapy could be useful for determining prognosis in women with locally advanced breast cancer. The patients were 37 women with locally advanced breast cancer who received preoperative chemotherapy between 1977 and 1987. The histological grade of malignancy (HCM) and histopathological therapeutic effects of chemotherapy (TEf) were examined in resected specimens. Patients with HGM 3 showed a poorer 10-year overall survival (38%) than those with HGM 1 or 2 (62%). Patients showing a better histopathological response (TEf 1b plus 2) had a poorer 10-year overall survival (20%) than those with a poorer response (TEf 0 plus la) (60%). Therapeutic effects were significantly related to histological grade, nuclear atypia and mitotic index (P=0.03, 0.005 and 0.002, respectively). Histopathological therapeutic effects were not directly correlated with patient prognosis. Cox proportional hazard regression analysis revealed that mitotic index was the most significant prognostic factor related to 10-year overall survival.

引用

页码：201 / 206

页数：6

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