Free radical enhancement promotes leucocyte recruitment through a PAF and LTB(4) dependent mechanism

被引：61

作者：

Hotter, G ^{[1
]}

Closa, D ^{[1
]}

Prats, N ^{[1
]}

Pi, F ^{[1
]}

Gelpi, E ^{[1
]}

RoselloCatafau, J ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,SCH VET,DEPT ANIM PATHOL,BELLATERRA,SPAIN

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1997年 / 22卷 / 06期

关键词：

adherence; PAF; LTB(4); oxygen free radical; inflammation; neutrophil;

D O I：

10.1016/S0891-5849(96)00494-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present investigation we studied the concerted role of superoxide anion, platelet activating factor (PAF) and leukotriene B-4 (LTB(4)) in the mechanism that results in polymorphonuclear leucocyte accumulation induced by oxygen free radicals in rat pancreas. This was done by comparing the effects of a PAF antagonist (BN-52021), a LTB(4) inhibitor (MK-886) and superoxide dismutase (SOD) in a experimental rat model of inflammation elicited by the oxygen free radicals induced via infusion of xanthine/xanthine oxidase. Also, the effect of independent LTB(4) infusion has been studied. The results show that increases in polymorphonuclear cell infiltration (evaluated by tissue histology), myeloperoxidase and LTB(4) levels induced in pancreas by infusion of xanthine/xanthine oxidase were abolished by the administration of either the PAF antagonist, the LTB(4) inhibitor, or SOD. The fact that BN-52021 could prevent neutrophil recruitment and LTB(4) synthesis suggests that PAF is a necessary step for subsequent LTB(4) synthesis and polymorphonuclear leucocyte accumulation. Copyright (C) 1997 Elsevier Science Inc.

引用

页码：947 / 954

页数：8

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