The production of nitric oxide and tumor necrosis factor by murine macrophages infected with mycobacterial strains differing by hemolytic activity

被引：5

作者：

Rudnicka, W

Brzychcy, M

Klink, M

Lopez, AG

Fonteyne, PA

Rüsch-Gerdes, S

Rózalska, B

机构：

[1] Univ Lodz, Dept Infect Biol, Inst Microbiol & Immunol, PL-90237 Lodz, Poland

[2] Polish Acad Sci, Dept Immunol, Microbiol & Virol Ctr, PL-93232 Lodz, Poland

[3] Inst Trop Med, Dept Microbiol, B-2000 Antwerp, Belgium

[4] Natl Reference Ctr Mycobacterium Forschungszentru, D-23845 Borstel, Germany

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1999年 / 43卷 / 07期

关键词：

mycobacteria; hemolysis; macrophages; nitric oxide; TNF;

D O I：

10.1111/j.1348-0421.1999.tb02451.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we compared the secretion of nitric oxide (NO) and tumor necrosis factor (TNF-alpha) by murine macrophages infected in vitro with hemolytic or unhemolytic mycobacteria isolates. We observed that unhemolytic mycobacteria induced more intensive NO production by macrophages and were more susceptible to bactericidal effect of mononuclear phagocytes than hemolytic mycobacterial strains. In contrast, the high-virulence hemolytic isolates induced significantly stronger TNF-alpha production by infected macrophages than the low-virulence unhemolytic bacilli.

引用

页码：637 / 644

页数：8

共 58 条

[1]

ADAMS LB, 1991, J IMMUNOL, V147, P1642

[2] Variations in the Nrampi gene and susceptibility to tuberculosis in West Africans [J].