Hypertension-Associated Kidney Disease: Perhaps no More

被引：81

作者：

Freedman, Barry I. ^{[1
]}

Sedor, John R. ^{[2
,3
,4
,5
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Nephrol Sect, Dept Internal Med, Winston Salem, NC 27157 USA

[2] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Sch Med, Dept Physiol, Cleveland, OH 44106 USA

[4] Case Western Reserve Univ, Sch Med, Dept Biophys, Cleveland, OH 44106 USA

[5] Rammelkamp Ctr Res & Educ, Kidney Dis Res Ctr, Cleveland, OH USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 19卷 / 11期

关键词：

D O I：

10.1681/ASN.2008060621

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Despite common wisdom, the role of essential hypertension in the etiopathogenesis of ESRD has been controversial. Two recently published studies demonstrated a strong association of genetic variants in the gene that encodes the molecular motor protein nonmuscle myosin 2a (MYH9) with ESRD in African American patients without diabetes. These new data demonstrate that much of the excess risk of ESRD in African American individuals is attributable to an MYH9 risk haplotype and suggest that hypertension may cause progressive kidney disease only in genetically susceptible individuals or be the result of a primary renal disease.

引用

页码：2047 / 2051

页数：5

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