The Genomic Landscape of Breast Cancer as a Therapeutic Roadmap

被引：173

作者：

Ellis, Matthew J. ^{[1
,2
,3
]}

Perou, Charles M. ^{[2
,3
,4
]}

机构：

[1] Washington Univ, Sch Med, Div Med Oncol, Sect Breast Oncol,Siteman Canc Ctr, St Louis, MO 63110 USA

[2] Univ Genom, St Louis, MO USA

[3] Bioclassifier LLC, St Louis, MO USA

[4] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA

来源：

CANCER DISCOVERY | 2013年 / 3卷 / 01期

关键词：

ESTROGEN-RECEPTOR-ALPHA; CELL-CYCLE CONTROL; INTRINSIC SUBTYPES; ENDOCRINE THERAPY; P53; PATHWAY; INHIBITION; MDM2; TUMORS; ACTIVATION; TAMOXIFEN;

D O I：

10.1158/2159-8290.CD-12-0462

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The application of high-throughput techniques to profile DNA, RNA, and protein in breast cancer samples from hundreds of patients has profoundly increased our knowledge of the disease. The etiologic events that drive breast cancer are finally coming into focus and should be used to set priorities for clinical trials. In this Prospective, we summarize some of the headline conclusions from 6 recent breast cancer "omics profiling" articles in Nature, with an emphasis on the implications for systemic therapy. Cancer Discov; 3(1); 27-34. (C) 2012 AACR.

引用

页码：27 / 34

页数：8

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