The effect of trans-ferulic acid and gamma-oryzanol on ethanol-induced liver injury in C57BL mouse

被引：65

作者：

Chotimarkorn, Chatchawan ^{[1
]}

Ushio, Hideki ^{[1
]}

机构：

[1] Tokyo Univ Marine Sci & Technol, Dept Food Sci & Technol, Minato Ku, Tokyo 1088477, Japan

来源：

PHYTOMEDICINE | 2008年 / 15卷 / 11期

关键词：

Trans-ferulic acid; Gamma-oryzanol; Protective action on liver injury; Ethanol and oxidative stress;

D O I：

10.1016/j.phymed.2008.02.014

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The effects of the oral administration of trans-ferulic acid and gamma-oryzanol (mixture of steryl ferulates) with ethanol (5.0 g per kg) for 30 days to c57BL mice on ethanol-induced liver injury were investigated. Preventions of ethanol-induced liver injury by trans-ferulic acid and gamma-oryzanol were reflected by markedly decreased serum activities of plasma aspartate aminotransferase, alanine aminotransferase and significant decreases in hepatic lipid hydroperoxide and TBARS levels. Furthermore, the trans-ferulic acid- and gamma-oryzanol-treated mice recovered ethanol-induced decrease in hepatic glutathione level together with enhancing superoxide dismutase activity. These results demonstrate that both trans-ferulic acid and gamma-oryzanol exert a protective action on liver injury induced by chronic ethanol ingestion. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：951 / 958

页数：8

共 42 条

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