Gastric Cancer, Version 2.2013 Featured Updates to the NCCN Guidelines

被引：435

作者：

Ajani, Jaffer A. ^{[1
]}

Bentrem, David J. ^{[2
]}

Besh, Stephen ^{[3
]}

D'Amico, Thomas A. ^{[4
]}

Das, Prajnan ^{[1
]}

Denlinger, Crystal ^{[5
]}

Fakih, Marwan G. ^{[6
]}

Fuchs, Charles S. ^{[7
]}

Gerdes, Hans ^{[8
]}

Glasgow, Robert E. ^{[9
]}

Hayman, James A. ^{[10
,11
]}

Hofstetter, Wayne L. ^{[1
]}

Ilson, David H. ^{[8
]}

Keswani, Rajesh N. ^{[2
]}

Kleinberg, Lawrence R. ^{[10
,11
]}

Korn, W. Michael ^{[12
]}

Lockhart, A. Craig ^{[13
,14
]}

Meredith, Kenneth ^{[15
]}

Mulcahy, Mary F.

Orringer, Mark B. ^{[10
,11
]}

Posey, James A. ^{[16
]}

Sasson, Aaron R. ^{[17
]}

Scott, Walter J. ^{[5
]}

Strong, Vivian E. ^{[7
]}

Varghese, Thomas K., Jr. ^{[18
]}

Warren, Graham ^{[17
,19
]}

Washington, Mary Kay ^{[20
]}

Willett, Christopher

Wright, Cameron D. ^{[21
]}

McMillian, Nicole R.

Sundar, Hema

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[2] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Evanston, IL 60208 USA

[3] Univ Tennessee, Hlth Sci Ctr, St Jude Childrens Res Hosp, Knoxville, TN 37996 USA

[4] Duke Canc Inst, Durham, NC USA

[5] Fox Chase Canc Ctr, Philadelphia, PA USA

[6] City Hope Comprehens Canc Ctr, Duarte, CA USA

[7] Dana Farber Brigham & Womens Canc Ctr, Boston, MA USA

[8] Mem Sloan Kettering Canc Ctr, New York, NY USA

[9] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[10] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[11] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA

[12] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

[13] Barnes Jewish Hosp, Siteman Canc Ctr, St Louis, MO USA

[14] Washington Univ, Sch Med, St Louis, MO USA

[15] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[16] Univ Alabama Birmingham Comprehens Canc Ctr, Birmingham, AL USA

[17] Nebraska Med Ctr, UNMC Eppley Canc Ctr, Omaha, NE USA

[18] Seattle Canc Care Alliance, Fred Hutchinson Canc Res Ctr, Seattle, WA USA

[19] Roswell Pk Canc Inst, Buffalo, NY USA

[20] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[21] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2013年 / 11卷 / 05期

关键词：

LYMPH-NODE DISSECTION; PHASE-III TRIAL; GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA; RANDOMIZED CLINICAL-TRIAL; GENE AMPLIFICATION; D2; GASTRECTOMY; PERIOPERATIVE CHEMOTHERAPY; HER2; EXPRESSION; SURGICAL TRIAL; STAGE-II;

D O I：

10.6004/jnccn.2013.0070

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer. For patients with resectable locoregional cancer, the guidelines recommend gastrectomy with a D1+ or a modified D2 lymph node dissection (performed by experienced surgeons in high-volume centers). Postoperative chemoradiation is the preferred option after complete gastric resection for patients with T3-T4 tumors and node-positive T1-T2 tumors. Postoperative chemotherapy is included as an option after a modified D2 lymph node dissection for this group of patients. Trastuzumab with chemotherapy is recommended as first-line therapy for patients with HER2-positive advanced or metastatic cancer, confirmed by immunohistochemistry and, if needed, by fluorescence in situ hybridization for IHC 2+.

引用

页码：531 / 546

页数：16

共 45 条

[1] Phase III study comparing a semimonthly with a monthly regimen of fluorouracil and leucovorin as adjuvant treatment for stage II and III colon cancer patients:: Final results of GERCOR c96.1 [J].

Andre, Thierry ;

Quinaux, Emmanuel ;

Louvet, Christophe ;

Colin, Philippe ;

Gamelin, Erik ;

Bouche, Olivier ;

Achille, Emmanuel ;

Piedbois, Pascal ;

Tubiana-Mathieu, Nicole ;

Boutan-Laroze, Arnaud ;

Flesch, Michel ;

Lledo, Gerard ;

Raoul, Yves ;

Debrix, Isabelle ;

Buyse, Marc ;

de Gramont, Aimery .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (24) :3732-3738

[2]

[Anonymous], J CLIN ONCOL S15

[3]

[Anonymous], J CLIN ONCOL S15

[4] Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial [J].

Bang, Yung-Jue ;

Kim, Young-Woo ;

Yang, Han-Kwang ;

Chung, Hyun Cheol ;

Park, Young-Kyu ;

Lee, Kyung Hee ;

Lee, Keun-Wook ;

Kim, Yong Ho ;

Noh, Sang-Ik ;

Cho, Jae Yong ;

Mok, Young Jae ;

Kim, Yeul Hong ;

Ji, Jiafu ;

Yeh, Ta-Sen ;

Button, Peter ;

Sirzen, Florin ;

Noh, Sung Hoon .

LANCET, 2012, 379 (9813) :315-321

[5] Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial [J].

Bang, Yung-Jue ;

Van Cutsem, Eric ;

Feyereislova, Andrea ;

Chung, Hyun C. ;

Shen, Lin ;

Sawaki, Akira ;

Lordick, Florian ;

Ohtsu, Atsushi ;

Omuro, Yasushi ;

Satoh, Taroh ;

Aprile, Giuseppe ;

Kulikov, Evgeny ;

Hill, Julie ;

Lehle, Michaela ;

Ruschoff, Josef ;

Kang, Yoon-Koo .

LANCET, 2010, 376 (9742) :687-697

[6] Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients [J].

Barros-Silva, J. D. ;

Leitao, D. ;

Afonso, L. ;

Vieira, J. ;

Dinis-Ribeiro, M. ;

Fragoso, M. ;

Bento, M. J. ;

Santos, L. ;

Ferreira, P. ;

Rego, S. ;

Brandao, C. ;

Carneiro, F. ;

Lopes, C. ;

Schmitt, F. ;

Teixeira, M. R. .

BRITISH JOURNAL OF CANCER, 2009, 100 (03) :487-493

[7] Extended lymph-node dissection for gastric cancer [J].

Bonenkamp, JJ ;

Hermans, J ;

Sasako, M ;

van de Velde, CJH .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (12) :908-914

[8] Clinicopathologic factors associated with HER2-positive gastric cancer and its impact on survival outcomes-A systematic review [J].

Chua, Terence C. ;

Merrett, Neil D. .

INTERNATIONAL JOURNAL OF CANCER, 2012, 130 (12) :2845-2856

[9] A prospective randomized study comparing D2 total gastrectomy versus D2 total gastrectomy plus splenectomy in 187 patients with gastric carcinoma [J].

Csendes, A ;

Burdiles, P ;

Rojas, J ;

Braghetto, I ;

Diaz, JC ;

Maluenda, F .

SURGERY, 2002, 131 (04) :401-407

[10] Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer [J].

Cunningham, David ;

Allum, William H. ;

Stenning, Sally P. ;

Thompson, Jeremy N. ;

Van de Velde, Cornelis J. H. ;

Nicolson, Marianne ;

Scarffe, J. Howard ;

Lofts, Fiona J. ;

Falk, Stephen J. ;

Iveson, Timothy J. ;

Smith, David B. ;

Langley, Ruth E. ;

Verma, Monica ;

Weeden, Simon ;

Chua, Yu Jo .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (01) :11-20

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