Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand

被引：24

作者：

Azahri, Nor Saadah M. ^{[1
,2
,3
]}

Kavurma, Mary M. ^{[1
]}

机构：

[1] Univ New S Wales, Ctr Vasc Res, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia

[3] Int Islamic Univ, Fac Allied Hlth Sci, Dept Biomed Sci, Kuantan 25200, Pahang, Malaysia

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 19期

关键词：

TRAIL; Transcription factor; Regulation; Gene expression; Apoptosis; Cell survival; NF-KAPPA-B; TRAIL-INDUCED APOPTOSIS; SMOOTH-MUSCLE-CELLS; BREAST-CANCER CELLS; INFLUENZA-VIRUS PROPAGATION; HUMAN ENDOTHELIAL-CELLS; HUMAN T-CELLS; GENE-EXPRESSION; MEDIATED APOPTOSIS; DEATH DOMAIN;

D O I：

10.1007/s00018-013-1264-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has dual functions mediating both apoptosis and survival of cells. This review focusses on the current regulatory factors that control TRAIL transcription. Here, we also highlight the role of distinct transcription factors that co-operate and regulate TRAIL in different pathological states. A better understanding of the molecular signalling pathways of TRAIL-induced cell death and survival in disease may lead to more sophisticated technologies for novel therapeutic targets.

引用

页码：3617 / 3629

页数：13

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