Expression of nestin after traumatic brain injury in rat brain

被引：105

作者：

Kaya, SS

Mahmood, A

Li, Y

Yavuz, E

Chopp, M

机构：

[1] Henry Ford Hlth Sci Ctr, Dept Neurosurg, Detroit, MI 48202 USA

[2] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI USA

[3] Oakland Univ, Dept Phys, Rochester, MI USA

来源：

BRAIN RESEARCH | 1999年 / 840卷 / 1-2期

关键词：

nestin; traumatic brain injury; astrocyte; microglia; plasticity;

D O I：

10.1016/S0006-8993(99)01757-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We tested the hypothesis that traumatic brain injury upregulates expression of nestin, an embryonic cell intermediate filament protein. Brain from rats (n = 24) subjected to controlled cortical impact injury and sham operated (n = 3) and normal(n = 3) rats were processed for dual label immunohistochemical study to identify cellular expression of nestin. Our results show that in normal noninjured animals, nestin is expressed slightly and localized only in a few endothelial and subventricular cells. In contrast, at 1-4 weeks postinjury nestin is strongly expressed in astrocytes and microglia. The expression of nestin in astrocytes and microglia after traumatic brain injury support the hypothesis that injured cerebral tissue expresses developmental proteins, and that these proteins may promote recovery after injury. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：153 / 157

页数：5

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